835633-47-1

Basic information

• Product Name: Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro-
• CAS NO: 835633-47-1
• Molecular Formula: C7H4BrF2NO3
• Molecular Weight: 268.014
• Mol File: 835633-47-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro-(835633-47-1)
• EPA Substance Registry System: Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro-(835633-47-1)

Safety Data

• Hazardous Substances Data: 835633-47-1(Hazardous Substances Data)

Usage

General Description

Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro- is a chemical compound with the molecular formula C7H5BrF2NO3. It is a nitro-substituted aromatic compound with a bromine and difluoromethoxy group attached to the benzene ring. Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro- is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of organic compounds and dyes. Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro- is a hazardous chemical and exposure to it should be avoided due to its potential toxicity and harmful effects on human health and the environment.

Upstream product

• 554-84-7 meta-nitrophenol 
• 52427-05-1 2-bromo-5-nitrophenol 
• 1895-39-2 sodium chlorodifluoroacetate 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 

Downstream Products

• 1150308-82-9 1-(2-difluoromethoxy-4-nitro-phenyl)-4-isopropyl-piperazine 
• 835633-46-0 1-(2-difluoromethoxy-4-nitrophenyl)piperazine 

Relevant articles and documents

COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS

Provided are compounds of Formula (I) which can be used as Syk inhibitors and potently as therapeutic agents against diseases mediated by Syk.

LACTAMS AS INHIBITORS OF ROCK

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES

The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula (1) and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.