83567-78-6

Basic information

• Product Name: [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester
• Synonyms: [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester
• CAS NO: 83567-78-6
• Molecular Weight: 339.233
• Mol File: 83567-78-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester(83567-78-6)
• EPA Substance Registry System: [1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester(83567-78-6)

Safety Data

• Hazardous Substances Data: 83567-78-6(Hazardous Substances Data)

Usage

General Description

[1,1-difluoro-2-hydroxy-2-(4-nitro-phenyl)-ethyl]-phosphonic acid diethyl ester is a chemical compound with the molecular formula C12H15F2NO7P. It is an organophosphorus compound, which is often used as a pesticide in agriculture to protect crops from insects and other pests. This chemical is highly toxic to insects and has low toxicity to mammals, making it an effective and widely used pesticide. However, it is important to handle and use this compound with great care due to its potential toxicity. Additionally, it is important to follow guidelines for its proper disposal and usage to minimize its environmental impact.

Upstream product

• 1478-53-1 Diethyl difluoromethylphosphonate 
• 555-16-8 4-nitrobenzaldehdye 
• 80077-72-1 diethyl difluoro(trimethylsilyl)methylphosphonate 
• 94993-99-4 diethyl difluoromethylphosphonate lithium salt 

Downstream Products

• 1742-99-0 1-(2,2-difluorovinyl)-4-nitrobenzene 
• 83567-82-2 Phosphoric acid 2,2-difluoro-1-(4-nitro-phenyl)-ethyl ester diethyl ester 

Relevant articles and documents

Siladifluoromethylation and Deoxo-trifluoromethylation of PV-H Compounds with TMSCF3: Route to PV-CF2- Transfer Reagents and P-CF3 Compounds

A method for siladifluoromethylation of dialkyl phosphonates and secondary phosphine oxides with TMSCF3 to produce nucleophilic PV-CF2- transfer reagents is disclosed, with multigram scale reactions included. Condition-dependent divergent reactivity under the established conditions is demonstrated by the formation of trifluoromethylphosphines. Both one-pot transformations are operationally simple and employ inexpensive materials. Mechanistic investigations suggest the divergent reactivity originates from a common intermediate, with Li+ concentration directing the chemoselectivity.

(DIETHYLPHOSPHINYL)DIFLUOROMETHYLLITHIUM. -PREPARATION AND SYNTHETIC APPLICATION-

The action of lithium diisopropylamide on diethyl difluoromethylphosphonate gives the title reagent which reacts with various electrophiles to introduce difluoromethylene or difluoromethyl unit.