83567-84-4

Basic information

• Product Name: 4-bromo-β,β-difluoro-α-methylstyrene
• Synonyms: 4-bromo-β,β-difluoro-α-methylstyrene
• CAS NO: 83567-84-4
• Molecular Weight: 233.055
• Mol File: 83567-84-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-bromo-β,β-difluoro-α-methylstyrene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-β,β-difluoro-α-methylstyrene(83567-84-4)
• EPA Substance Registry System: 4-bromo-β,β-difluoro-α-methylstyrene(83567-84-4)

Safety Data

• Hazardous Substances Data: 83567-84-4(Hazardous Substances Data)

Upstream product

• 1219454-89-3 2-((difluoromethyl)sulfonyl)pyridine 
• 99-90-1 para-bromoacetophenone 
• 1895-39-2 sodium chlorodifluoroacetate 
• 136476-20-5 1-bromo-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1449521-17-8 [tris(dimethylamino)phosphonio]difluoroacetate 
• 94993-99-4 diethyl difluoromethylphosphonate lithium salt 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 

Downstream Products

• 1236300-62-1 (Z)-1-bromo-4-(1-fluoroprop-1-en-2-yl)benzene 

Relevant articles and documents

Chalcogenide-Catalyzed Intermolecular Electrophilic Thio- And Halofunctionalization of gem-Difluoroalkenes: Construction of Diverse Difluoroalkyl Sulfides and Halides

Thio- and halodifluoromethylated compounds are an important class of compounds in medicinal chemistry and organic synthesis. Herein, we report a facile method for the construction of these compounds via chalcogenide-catalyzed intermolecular electrophilic thio- and halofunctionalization of gem-difluoroalkenes. Simple treatment of gem-difluoroalkenes with electrophilic sulfur/halogen reagents and various O- or N-nucleophiles affords diverse multifunctionalized thio- and halodifluoromethylated compounds. This reaction features a relatively broad substrate scope, good functional group tolerance, and mild reaction conditions.

Photocatalytic alkene reduction by a B12-TiO2 hybrid catalyst coupled with C-F bond cleavage for: Gem -difluoroolefin synthesis

Photocatalytic syntheses of gem-difluoroolefins were performed using the B12-TiO2 hybrid catalyst during the CC bond reduction of α-trifluoromethyl styrenes with C-F bond cleavage at room temperature under nitrogen. The gem-difluoroolefins were used as synthetic precursors for fluorinated cyclopropanes.

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.