83567-91-3Relevant academic research and scientific papers
Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate
Alexandrova, Anastasia V.,Beier, Petr
scheme or table, p. 493 - 500 (2009/12/06)
A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and anti 2,2-difluoro-1,3-diols.
An efficient and highly selective synthesis of (Z)-fluoroenol phosphates from hydroxy difluorophosphonates
Beier, Petr,Pohl, Radek,Alexandrova, Anastasia V.
experimental part, p. 957 - 962 (2009/12/03)
Substituted 2-aryl-2-hydroxy-1,1-difluorophosphonates undergo a reaction with potassium tert-butoxide to provide selectively (Z)-2-fluoro-1-arylvinyl phosphates in high yields. Georg Thieme Verlag Stuttgart.
Nucleophilic difluoromethylation and difluoromethylenation of aldehydes and ketones using diethyl difluoromethylphosphonate
Beier, Petr,Alexandrova, Anastasia V.,Zibinsky, Mikhail,Surya Prakash
scheme or table, p. 10977 - 10985 (2009/04/11)
New methodology for difluoromethylation and difluoromethylenation of aldehydes and ketones based on nucleophilic fluorination using diethyl difluoromethylphosphonate (1) was developed.
(DIETHYLPHOSPHINYL)DIFLUOROMETHYLLITHIUM. -PREPARATION AND SYNTHETIC APPLICATION-
Obayashi, Michio,Ito, Eiji,Matsui, Kiyohide,Kondo, Kiyosi
, p. 2323 - 2326 (2007/10/02)
The action of lithium diisopropylamide on diethyl difluoromethylphosphonate gives the title reagent which reacts with various electrophiles to introduce difluoromethylene or difluoromethyl unit.
