83567-99-1Relevant academic research and scientific papers
Nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate
Alexandrova, Anastasia V.,Beier, Petr
experimental part, p. 493 - 500 (2009/12/06)
A new nucleophilic difluoromethylenation of aldehydes and ketones using diethyl difluoro(trimethylsilyl)methylphosphonate (1) has been achieved. The reactive carbanion species were generated under mild reaction conditions with a catalytic amount of initiator. This methodology was compatible with non-enolizable and in some cases with enolizable aldehydes and ketones and provided a straightforward access to phosphates of syn and anti 2,2-difluoro-1,3-diols.
AN IMPROVED PROCEDURE FOR THE SYNTHESIS OF 1,1-DIFLUORO-2-HYDROXYALKYLPHOSPHONATES
Obayashi, Michio,Kondo, Kiyosi
, p. 2327 - 2328 (2007/10/02)
The reaction of diethyl difluoro(trimethylsilyl)methylphosphonate with arenecarbaldehydes and aryl methyl ketones is effected with the aid of a catalyst, cesium fluoride, at room temperature to afford the title compounds.
