83568-11-0

Usage

Uses

Used in Pharmaceutical Industry:
2H-Pyran-2-carboxylic acid, 3,4-dihydro-, ethyl ester serves as an intermediate in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and medicinal agents.
Used in Agricultural Products:
In the agricultural sector, this chemical compound is employed in the production of agrochemicals, aiding in the development of effective pest control and crop protection solutions.
Used in Fragrance and Flavor Industry:
2H-Pyran-2-carboxylic acid, 3,4-dihydro-, ethyl ester is used as a component in the creation of fragrances and flavoring additives, enhancing the sensory qualities of various consumer products.
Safety Precautions:
It is crucial to handle 2H-Pyran-2-carboxylic acid, 3,4-dihydro-, ethyl ester with care due to its potential to cause irritation to the skin, eyes, and respiratory system. It should be stored in a cool, dry place, away from heat and direct sunlight to ensure stability and safety.

InChI:InChI=1/C8H12O3/c1-2-10-8(9)7-5-3-4-6-11-7/h4,6-7H,2-3,5H2,1H3

Upstream product

• 100-73-2 acrolein dimer 
• 16698-52-5 3,4-dihydro-2H-pyran-2-carboxylic acid sodium salt 
• 75-03-6 ethyl iodide 
• 110811-34-2 ethyl tetrahydro-2H-pyran-2-carboxylate 
• 34201-01-9 3,4-dihydro-2H-pyran-2-carboxylic acid 

Downstream Products

• 5257-20-5 7-Oxo-6,8-dioxabicyclo<3.2.1>octane 
• 3749-36-8 2-hydroxymethyl-3,4-dihydro-2H-pyran 
• 49831-28-9 3,4-Dihydro-2H-pyran-carbonsaeure-(2)-amid 

Relevant academic research and scientific papers

Manganese-Catalyzed Desaturation of N-Acyl Amines and Ethers

Enamines and enol ethers are versatile synthons for chemical synthesis. While several methods have been developed to access such molecules, prefunctionalized starting materials are usually required, and direct desaturation methods remain rare. Herein, we report direct desaturation reactions of N-protected cyclic amines and cyclic ethers using a mild I(III) oxidant, PhI(OAc)2, and an electron-deficient manganese pentafluorophenylporphyrin catalyst, Mn(TPFPP)Cl. This system displays high efficiency for α,β-desaturation of various cyclic amines and ethers. Mechanistic probes suggest that the desaturation reaction occurs via an initial α-C-H hydroxylation pathway, which serves to protect the product from overoxidation.

CCR2 MODULATORS

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I) and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

SYNTHESIS OF BROMO-SUBSTITUTED BICYCLIC OXALACTAM AND UNUSUAL ANIONIC DESALTING OLIGOMERIZATION OF ITS SODIUM SALT

New bromo-substituted bicyclic oxalactam, 4(e)-bromo-8-oxa-6-azabicyclooctan-7-one (1) was synthesized from sodium 3,4-dihydro-2H-pyran-2-carboxylate.Sodium salt of 1 was found to be oligomerized with the simultaneous desalting in dimethylformamide at 25 degC to give novel oligomers having a bicyclic oxalactam ring in each monomer unit.