83570-32-5Relevant articles and documents
1,4-naphthoquinone cations as antiplasmodial agents: Hydroxy-, acyloxy-, and alkoxy-substituted analogues
Lu, Xiao,Altharawi, Ali,Gut, Jiri,Rosenthal, Philip J.,Long, Timothy E.
supporting information, p. 1029 - 1033 (2013/02/22)
Cations of hydroxy-substituted 1,4-naphthoquinones were synthesized and evaluated as antiplasmodial agents against Plasmodium falciparum. The atovaquone analogues were found to be inactive as antagonists of parasite growth, which was attributed to ionization of the acidic hydroxyl moiety. Upon modification to an alkoxy substituent, the antiplasmodial activity was restored in the sub-100 nM range. Optimal inhibitors were found to possess IC50 values of 17.4-49.5 nM against heteroresistant P. falciparum W2.
Synthesis of atovaquone
Williams, David R.,Clark, Michael P.
, p. 7629 - 7632 (2007/10/03)
A short synthesis of atovaquone I is achieved via the radical coupling of the trans-1,4-substituted cyclohexyl mono-oxalate 2 and 2- chloronapthoquinone under phase transfer conditions.
Method for the hydrocarbylation of naphthoquinone derivatives
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, (2008/06/13)
A method for the hydrocarbylation of naphthoquinones comprising cross-coupling addition of the hydrocarbyl moiety of selected organometallic reagents to leaving group-substituted naphthoquinones.