83605-16-7Relevant academic research and scientific papers
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
Nersesian, Diana L.,Black, Lawrence A.,Miller, Thomas R.,Vortherms, Timothy A.,Esbenshade, Timothy A.,Hancock, Arthur A.,Cowart, Marlon D.
, p. 355 - 359 (2008/04/03)
Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
Benzothiazepine vasodilators having aralkyl substitution
-
, (2008/06/13)
N-Aminoalkyl 1,5-benzothiazepines of the following formula (I): STR1 for the treatment of angina or hypertension or the prevention of heart attacks in mammals, in particular their use as coronary vasodilators.
Synthesis and Pharmacological Studies of 4,4-Disubstituted Piperidines: A New Class of Compounds with Potent Analgesic Properties
Huegi, Bruno S.,Ebnoether, Anton M.,Rissi, Erwin,Gadient, Fulvio,Hauser, Daniel,et al.
, p. 42 - 50 (2007/10/02)
A series of 4,4-disubstituted piperidines has been synthesized and evaluated for analgesic activity.Several of these analogues show analgesic potency comparable to morphine in the mouse writhing and tail-flick tests.A number of compounds exhibit high affi
