89545-43-7

Upstream product

• 125814-33-7 N-(tert-butoxycarbonyl)-L-leucine N-carboxyanhydride 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 41324-66-7 H-Pro-OBzl 
• 132548-05-1 Nps-Leu-Pro-OBzl 
• 83610-44-0 benzyl (2S)-1-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanoyl]pyrrolidine-2-carboxylate 

Downstream Products

• 118171-81-6 TBDMS-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl 
• 89545-44-8 Boc-Orn(Z)-Leu-Pro-OBzl 
• 387823-12-3 N-(N-(α-hydroxyisovaleryl)leucyl)proline benzyl ester 
• 118171-82-7 H-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl 
• 83610-72-4 Boc-Ile-Leu-Pro-OBn 
• 96625-33-1 Boc-Gly(OH)-Leu-Pro-ONp 
• 89545-48-2 Boc-Asn-Val-Orn(Z)-Leu-Pro-OBzl 
• 89545-50-6 Boc-Asn-Val-Orn(Z)-Leu-Pro-N₂H₃ 
• 89545-46-0 Boc-Val-Orn(Z)-Leu-Pro-OBzl 
• 161007-43-8 Boc-Lys(Z)-Gln-Leu-Pro-OBzl 
• 945473-52-9 C₄₂H₆₅N₅O₁₂ 
• 766513-83-1 C₄₂H₆₇N₅O₁₃ 
• 766513-82-0 C₅₇H₇₉N₅O₁₅ 
• 766513-99-9 1-{2-[2-(4-{3-[2-(benzyloxycarbonyl-methyl-amino)-3-naphthalen-2-yl-propionyloxy]-2-tert-butoxycarbonylamino-butyrylamino}-3-hydroxy-5-methyl-hexanoyloxy)-3-methyl-butyrylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Environmentally benign peptide synthesis using liquid-assisted ball-milling: Application to the synthesis of Leu-enkephalin

This paper describes an original methodology for peptide bond synthesis avoiding toxic solvents and reactants. Ball-milling stoichiometric amounts of Boc-protected α-amino acid N-carboxyanhydrides (Boc-AA-NCA) or Boc-protected α-amino acid N-hydroxysuccin

An efficient synthesis of the tamandarin B macrocycle

A reliable, high yielding cyclization protocol for the macrocycle of tamandarin B is presented. This strategy will facilitate the synthesis of side chain analogs.

SYNTHESIS OF FRAGMENTS OF THE VP1 PROTEIN OF TYPE A22 FOOT-AND-MOUTH DISEASE VIRUS. SYNTHESIS OF FRAGMENTS 134-139, 134-145, 140-145, 150-155, AND 150-159

Fragments of peptides of the amino acid sequences (134-145) and (150-159) of the VP1 protein of the type A22 foot-and-mouth disease (FMD)virus have been synthesized by the classical methods of peptide chemistry.Oligopeptides were obt

Efficient total synthesis of didemnins A and B

Didemnins A and B (1 and 2), cytotoxic cyclic peptides from a Caribbean tunicate Trididemnum solidum, have been efficiently prepared by a convergent scheme from two key eastern and western fragments. Efficient routes to derivatives of the constituents of didemnis were explored. Benzyl (2RS,4S)-[O-(tert-butyldimethylsilyl)hydroxyisovaleryl]propionate (Hip derivative) was prepared from 2-hydroxyisovaleric acid by use of C-acylation of Meldrum's acid with diethyl phosphorocyanidate as a key step. Derivatives of (3S,4R,5S)-isostatine (Ist) were prepared from Boc-(R)-alloisoleucine. Methylation of Boc-(R)-Leu-OH and Z-(S)-Tyr-OH respectively afforded the corresponding N-methyl and N,O-dimethyl derivatives. The key eastern fragment, (2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl (3), was prepared stepwise from (S)-Pro-OBzl, while Boc-(R)-MeLeu-(S)-Thr[Z-(S)-MeTyr(Me)]-(3S,4R,5S)-Ist(TBDMS)-OH (4), the key western fragment for didemnin A (1), was prepared from Ist derivatives. Coupling of 3 with 4 and cyclization, followed by deprotection, afforded didemnin A (1), which was converted to didemnin B (2).

Studies on the β-turn of peptides. VII. Syntheses and antibiotic activities of gramicidin S analogs with L-Pro-L-Asn or L-Pro-d-Ala sequence at the β-turn part

Two analogs of gramicidin S (GS), left bracket L-Pro**4**,**4 prime , L-Asn**5**,**5 prime right bracket -GS and left bracket L-Pro**4**,**4 prime , D-Ala**5**,**5 prime right bracket -GS were synthesized to investigate the possibility of replacing the be