83647-40-9Relevant articles and documents
Heterocyclic substituted biphenyl compound as well as preparation method and application thereof
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, (2021/08/28)
The invention discloses a heterocyclic substituted biphenyl compound as well as a preparation method and application thereof. According to the present invention, the compound can block the PD-1/PD-L1 signal pathway, and can be used as the immune checkpoint PD-1/PD-L1 small molecule inhibitor; and according to the compound disclosed by the invention, the metabolic stability is improved while the high binding rate with PD-L1 protein is maintained. A hydrophilic group is introduced to a heterocyclic ring, and the PD-1/PD-L1 inhibitory activity is improved.
IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF
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Page/Page column 17-18, (2020/02/14)
Provided are compounds of formula I, pharmaceutical compositions thereof, and methods of using the compounds as immunomodulators. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.
METHODS OF PROMOTING BETA CELL PROLIFERATION
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, (2018/06/30)
The present disclosure provides methods of promoting proliferation of a pancreatic cell. The methods are useful for the treatment of diabetes and other diseases characterized by impaired glucose tolerance.