83647-40-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-2-methyl-benzaldehyde is used as an intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows it to be a key component in the creation of different medicinal compounds, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-2-methyl-benzaldehyde serves as an intermediate for the synthesis of various agrochemicals. Its role in this industry is crucial for the production of substances that help in enhancing crop protection and yield.
Used in Organic Compounds Synthesis:
3-Bromo-2-methyl-benzaldehyde is used as an intermediate in the synthesis of a range of organic compounds. Its versatility in chemical reactions makes it a valuable component in organic chemistry for creating diverse molecules with specific applications.
Used in Fragrance and Flavoring Industry:
Leveraging its strong and characteristic odor, 3-Bromo-2-methyl-benzaldehyde is used in the production of fragrances and flavoring agents. It adds unique scents and tastes to various consumer products, enhancing their appeal.
Used in Research for Biological Activities:
3-Bromo-2-methyl-benzaldehyde has been studied for its potential biological activities, such as antibacterial and antifungal properties. This research explores its use in developing new treatments and applications in the field of biology and medicine.

Upstream product

• 83647-43-2 3-bromo-2-methylbenzyl alcohol 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 69321-60-4 2,6-dibromotoluene 
• 68-12-2 N,N-dimethyl-formamide 
• 631909-08-5 3-bromo-N-methoxy-2, N-dimethylbenzamide 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 1089206-03-0 ethyl (E)-3-(3-bromo-2-methylphenyl)acrylate 
• 50536-58-8 5-bromo-4-methyl-1H-indole-2-carboxylic acid 
• 1857296-39-9 methyl 5-bromo-4-methyl-1H-indole-2-carboxylate 
• 76574-42-0 2-(3-bromo-2-methyl-phenyl)acetonitrile 
• 1148024-99-0 (3-bromo-2-methyl-phenyl)methyl methanesulfonate 
• 83647-43-2 3-bromo-2-methylbenzyl alcohol 

Relevant academic research and scientific papers

Heterocyclic substituted biphenyl compound as well as preparation method and application thereof

The invention discloses a heterocyclic substituted biphenyl compound as well as a preparation method and application thereof. According to the present invention, the compound can block the PD-1/PD-L1 signal pathway, and can be used as the immune checkpoint PD-1/PD-L1 small molecule inhibitor; and according to the compound disclosed by the invention, the metabolic stability is improved while the high binding rate with PD-L1 protein is maintained. A hydrophilic group is introduced to a heterocyclic ring, and the PD-1/PD-L1 inhibitory activity is improved.

IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF

Provided are compounds of formula I, pharmaceutical compositions thereof, and methods of using the compounds as immunomodulators. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833

Herein we describe our efforts using a late stage functionalization together with more traditional synthetic approaches to generate fluorinated analogues of the clinical candidate AZD9833. The effects of the addition of fluorine on the lipophilicity, permeability, and metabolism are discussed. Many of these changes were tolerated in terms of pharmacology and resulted in high quality molecules which reached advanced stages of profiling in the testing cascade.

Regioselective Functionalization of 4-Methyl-1H-indole for Scalable Synthesis of 2-Cyano-5-formyl-4-methyl-1H-indole

We report a five-step synthesis of 2-cyano-5-formyl-4-methyl-1H-indole through sequential functionalization of readily available 4-methyl-1H-indole. Cyano and aldehyde functionalities are regioselectively installed at the 2 and 5 position, respectively. T

METHODS OF PROMOTING BETA CELL PROLIFERATION

The present disclosure provides methods of promoting proliferation of a pancreatic cell. The methods are useful for the treatment of diabetes and other diseases characterized by impaired glucose tolerance.

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

CHEMICAL COMPOUNDS

The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

INDAZOLE DERIVATIVES THAT DOWN-REGULATE THE ESTROGEN RECEPTOR AND POSSESS ANTI-CANCER ACTIVITY

The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS

Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

Development of potent small molecule inhibitors of protein-protein interactions with optimized druglike properties represents a challenging task in lead optimization process. Here, we report synthesis and structure-based optimization of new thienopyrimidine class of compounds, which block the protein-protein interaction between menin and MLL fusion proteins that plays an important role in acute leukemias with MLL translocations. We performed simultaneous optimization of both activity and druglike properties through systematic exploration of substituents introduced to the indole ring of lead compound 1 (MI-136) to identify compounds suitable for in vivo studies in mice. This work resulted in the identification of compound 27 (MI-538), which showed significantly increased activity, selectivity, polarity, and pharmacokinetic profile over 1 and demonstrated a pronounced effect in a mouse model of MLL leukemia. This study, which reports detailed structure-activity and structure-property relationships for the menin-MLL inhibitors, demonstrates challenges in optimizing inhibitors of protein-protein interactions for potential therapeutic applications.