83686-32-2

Upstream product

• 83686-28-6 ethyl 4-(2′,3′-O-isopropylidene-5′-O-trityl-D-ribofuranosyl)-3-oxobutanoate 
• 54503-64-9 2,3-O-isopropylidene-5-O-trityl-D-ribofuranose 
• 13148-05-5 ethyl 3-oxo-4-(triphenylphosphoranylidene)butanoate 

Downstream Products

• 83686-33-3 4-hydroxy-3-(2′,3′-O-isopropylidene-5′-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxamide 
• 90524-85-9 methyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate 
• 30868-30-5 pyrazofurin 
• 30868-30-5 pyrazofurin B 
• 90524-78-0 3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-1H,6H-pyrazolo<3,4-e><1,3>oxazine-5,7-dione 
• 90524-84-8 3-β-D-ribofuranosylpyrazolo<3,4-e><1,3>oxazine-5,7-dione 
• 84955-76-0 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-5-morpholinocarbonylpyrazole 
• 84955-74-8 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-5-pyrrolidin-1-ylcarbonylpyrazole 

Relevant academic research and scientific papers

The first chemical synthesis of pyrazofurin 5′-triphosphate

As an archetype C-nucleoside, pyrazofurin possesses broad-spectrum antiviral and antitumor activities. However, the presence of the acidic enol in the nucleobase of pyrazofurin poses a huge challenge to the conventional NTP synthetic methods. On the basis

Synthesis of Pyrazofurin and its Analogues

Pyrazofurin and its analogues have been synthesized fron ribosyl β-keto acid derivatives, which can be readily prepared by Wittig reaction of the protected D-ribose with phosphoranes.Reaction of 2,3-O-isopropylidene-5-O-trityl-α- and β-D-ribose (6) with 3

A Simple Synthesis of the Pyrazofurins

Pyrazofurin (1) and pyrazofurin B (2) have been synthesised from the β-keto ester (5), which can be readily prepared by Wittig reaction of the protected D-ribose (3) with the phosphorane (4).