83697-75-0Relevant articles and documents
Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives
Oh, Taegwon,Hayat, Aisal,Yoo, Euna,Cho, Sang-Nae,Sheen, Yhun Yhung,Kim, Dae-Kee,Choo, Hea-Young Park
, p. 43 - 51 (2015/03/04)
1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 ??M. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.
HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS
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, (2011/09/16)
Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a thiazole ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
STUDIES ON THE MOESSBAUER SPECTRA OF SOME IRON(III) COMPLEXES WITH IMIDES AS PRIMARY AND SOME N-ARYL-N'-BENZOYLTHIOCARBAMIDES AS SECONDARY LIGANDS. EFFECT OF AMBIENT TEMPERATURE
Mishra, Virendra
, p. 155 - 161 (2007/10/02)
Ten new mixed ligand complexes of iron(III) of the type , where Im = deprotonated phthalimide or succinimide and STC = some N-aryl-N'-benzoylthiocarbamide derivativesN-(2-chlorophenyl)-N'-benzoylthiocarbamide, N-(3-methoxyphenyl)-N'-be