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Usage

Uses

Used in Organic Synthesis:
2,2,2-Trifluoro-N-(naphthalen-1-yl)acetamide is utilized as a building block in organic synthesis, particularly for the creation of biologically active molecules. Its electronegative nature and aromatic properties make it a valuable component in the synthesis of complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,2,2-trifluoro-N-(naphthalen-1-yl)acetamide is employed as a key intermediate in the development of new drugs. Its unique structure and reactivity allow for the exploration of potential therapeutic agents, with the aim of discovering novel treatments for various diseases and conditions.
Used in Chemical Processes:
2,2,2-Trifluoro-N-(naphthalen-1-yl)acetamide is also used in certain chemical processes due to its electronegative and aromatic properties. Its reactivity can be harnessed to facilitate specific reactions, making it a useful compound in the field of chemistry.

Upstream product

• 134-32-7 1-amino-naphthalene 
• 407-25-0 trifluoroacetic anhydride 
• 96254-05-6 2-(trifluoroacetyloxy)pyridine 
• 354-38-1 2,2,2-trifluoroacetamide 
• 90-11-9 1-Bromonaphthalene 
• 90-14-2 1-Iodonaphthalene 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 78977-68-1 N-(γ-phenylallyl)-N-trifluoroacetyl-1-naphthylamine 
• 1001098-42-5 C₂₁H₁₆F₃NO 
• 22950-23-8 N-(2-propenyl)-1-naphthylamine 
• 22774-95-4 N-cinnamyl-α-naphthylamine 
• 112983-35-4 (+)-8,9-benzo-10-butyl-3-(R)-α-methylbenzyl-5-deazaflavin 
• 79630-21-0 4-methyl-N-(naphthalen-1-yl)benzamide 

Relevant academic research and scientific papers

Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage

The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are well tolerated. These moisture-stable and easily available trifluoroacetyl amides can be conveniently obtained and used as new versatile precursors for isocyanates. The control experiments show that the reaction proceeds via an isocyanate intermediate and/or alkoxide/amide dual anionic intermediate.

A one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid as a trifluoroacetylating reagent

A convenient procedure for the preparation of aryl trifluoroacetamides from aryl amines is described that employs 2-4 M equiv of trifluoroacetic acid in refluxing xylene as a trifluoroacetylating agent. Addition of an amount of pyridine that is equimolar to the amount of trifluoroacetic acid present in the reaction mixture facilitates the trifluoroacetylation of rather basic arylamines.

Copper-catalyzed synthesis of primary arylamines from aryl halides and 2,2,2-trifluoroacetamide

A catalytic method was developed to synthesize primary arylamines from the corresponding aryl bromides and iodides under mild conditions (yields = 80-99%). Crystalline 2,2,2-trifluoroacetamide was used as ammonia surrogate and CuI/N,N′-dimethyl ethylenediamine was used as catalyst to achieve the C-N cross-coupling.

COLOURED ORGANIC ELECTROPHORETIC PARTICLES

The present invention relates to the preparation and use of (colored) organic particles carrying electric charge as electrophoretic (image) displaying particles, to electrophoretic dispersions comprising the organic particles carrying electric charge, ele

SURFACE-MODIFIED NANOPARTICLES COMPRISING A CATIONIC COLORANT FOR USE IN COLOR FILTERS

Color filter comprising a surface-modified nanoparticle wherein a cationic colorant is covalently attached to the surface of said nanoparticle, a polymerizable mixture for making color filters, a surface-modified nanoparticle and its use.

2-(Trifluoroacetyloxy)pyridine as a Mild Trifluoroacetylating Reagent of Amines and Alcohols

A new trifluoroacetylating reagent, 2-(trifluoroacetyloxy)pyridine (TFAP), was prepared by the reaction of 2-pyridinol and trifluoroacetic anhydride.TFAP has been found to be effective in the trifluoroacetylation of aliphatic and aromatic amines and alcohols including phenol under mild conditions.The reaction of p-nitrophenol with TFAP in ether gave the hydrogen-bonded complex between the phenol and 2-pyridone.This reagent has also been shown to be useful for the intramolecular dehydration of aldehyde oximes and amides to give nitriles in high yields.

Oxygen Sensitization of Electron Capture Response to Isomers of Polycyclic Aromatic Amines and Hydroxides

The use of the oxygen-sensitized constant-current electron capture detector (ECD) with gas chromatography for analyte identification is extended by examining the responses of numerous polycyclic aromatic amines and hydroxides where an appropriate EC-enhancing chemical tag has been attached to the amino group or the hydroxy group has been methylated.For the majority of isomeric groups examined, measured response enhancements of the derivatives are sufficiently dependent on structural differences as to provide an additional means by which substitution isomers can be differentiated.The ion chemistry responsible for the EC and oxygen-sensitized responses also has been examined by the use of an atmospheric pressure ionization mass spectrometer (APIMS).