83704-88-5

Usage

Chemical structure

1',2',3',4',5',6'-hexahydrohomofolic acid is a chemical compound that is structurally similar to folic acid, which is essential for the synthesis of DNA, RNA, and proteins.

Derivative

It is a derivative of homofolic acid, which plays a crucial role in one-carbon metabolism and is involved in the transfer of methyl groups.

Therapeutic uses

1',2',3',4',5',6'-hexahydrohomofolic acid has been studied for its potential therapeutic uses, including as a treatment for certain types of cancer and as a means to improve the bioavailability of folate.

Cofactor

It has been shown to act as a cofactor for various enzymes involved in cellular metabolism.

Applications

1',2',3',4',5',6'-hexahydrohomofolic acid may have applications in the development of new pharmaceuticals and dietary supplements.

Bioavailability

It has been studied as a means to improve the bioavailability of folate, which is essential for various cellular processes.

One-carbon metabolism

It plays a crucial role in one-carbon metabolism, which is involved in the transfer of methyl groups and the synthesis of essential biomolecules.

Cellular metabolism

1',2',3',4',5',6'-hexahydrohomofolic acid is involved in cellular metabolism and may have applications in the development of new pharmaceuticals and dietary supplements.

Structural similarity

It is structurally similar to folic acid, which is essential for the synthesis of DNA, RNA, and proteins.

Potential for research

Further research is needed to fully understand the potential therapeutic uses and applications of 1',2',3',4',5',6'-hexahydrohomofolic acid in the development of new pharmaceuticals and dietary supplements.

InChI:InChI=1/C20H27N7O6/c21-20-26-16-15(18(31)27-20)24-12(9-23-16)7-8-22-11-3-1-10(2-4-11)17(30)25-13(19(32)33)5-6-14(28)29/h9-11,13,22H,1-8H2,(H,25,30)(H,28,29)(H,32,33)(H3,21,23,26,27,31)/t10?,11?,13-/m0/s1

Upstream product

• 83710-11-6 4-[{2-[4-Oxo-2-(2,2,2-trifluoro-acetylamino)-3,4-dihydro-pteridin-6-yl]-ethyl}-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid 
• 83704-96-5 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4--2,2-(ethylenedioxy)butane 
• 83704-97-6 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one 
• 83704-98-7 4-[[4-(2,5-Diamino-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-3-oxo-butyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-99-8 4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-94-3 1-azido-4--2,2-(ethylenedioxy)butane 
• 83704-93-2 1-azido-4-butane-2-one 
• 83704-95-4 4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-91-0 4-[(2-Chlorocarbonyl-ethyl)-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-90-9 N-(trifluoroacetyl)-N-(4-carbethoxycyclohexyl)-β-alanine 
• 83704-92-1 1-bromo-4-butane-2-one 
• 83705-00-4 1',2,',3',4',5',6'-hexahydrohomopteroic acid 
• 83704-89-6 N-(4-carbethoxycyclohexyl)-β-alanine 
• 6959-76-8 3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid 

Relevant academic research and scientific papers

Folate Analogues. 20. Synthesis and Antifolate Activity of 1',2',3',4',5',6'-Hexahydrohomofolic Acid

The synthesis of 1',2',3',4',5',6'-hexahydrohomofolic acid (3), a close analogue of homofolic acid (2), has been carried out by replacement of the benzene ring of 2 with a cyclohexane ring.The synthetic methods employed here were based on the Boon-Leigh s