83705-00-4

Upstream product

• 83704-99-8 4-[[2-(2-Amino-4-oxo-3,4-dihydro-pteridin-6-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 6959-76-8 3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid 
• 83704-89-6 N-(4-carbethoxycyclohexyl)-β-alanine 
• 83704-92-1 1-bromo-4-butane-2-one 
• 83704-90-9 N-(trifluoroacetyl)-N-(4-carbethoxycyclohexyl)-β-alanine 
• 83704-91-0 4-[(2-Chlorocarbonyl-ethyl)-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-95-4 4-[[2-(2-Aminomethyl-[1,3]dioxolan-2-yl)-ethyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-93-2 1-azido-4-butane-2-one 
• 83704-94-3 1-azido-4--2,2-(ethylenedioxy)butane 
• 83704-98-7 4-[[4-(2,5-Diamino-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-3-oxo-butyl]-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid ethyl ester 
• 83704-97-6 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one 
• 83704-96-5 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4--2,2-(ethylenedioxy)butane 

Downstream Products

• 83710-11-6 4-[{2-[4-Oxo-2-(2,2,2-trifluoro-acetylamino)-3,4-dihydro-pteridin-6-yl]-ethyl}-(2,2,2-trifluoro-acetyl)-amino]-cyclohexanecarboxylic acid 
• 83704-88-5 1',2',3',4',5',6'-hexahydrohomofolic acid 

Relevant academic research and scientific papers

Folate Analogues. 20. Synthesis and Antifolate Activity of 1',2',3',4',5',6'-Hexahydrohomofolic Acid

The synthesis of 1',2',3',4',5',6'-hexahydrohomofolic acid (3), a close analogue of homofolic acid (2), has been carried out by replacement of the benzene ring of 2 with a cyclohexane ring.The synthetic methods employed here were based on the Boon-Leigh s