83725-78-4

Basic information

• Product Name: 1,3,4-Oxadiazol-2(3H)-one, 5-(4-methylphenyl)-
• CAS NO: 83725-78-4
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.175
• Mol File: 83725-78-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazol-2(3H)-one, 5-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazol-2(3H)-one, 5-(4-methylphenyl)-(83725-78-4)
• EPA Substance Registry System: 1,3,4-Oxadiazol-2(3H)-one, 5-(4-methylphenyl)-(83725-78-4)

Safety Data

• Hazardous Substances Data: 83725-78-4(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Nitrogen-containing five-membered ring with oxygen and nitrogen atoms at adjacent positions

Functional groups

Oxadiazol-2(3H)-one and 4-methylphenyl

Potential applications

Pharmaceutical and medicinal properties

Biological activities

Antimicrobial and anti-inflammatory agent

Research significance

Interesting target for drug discovery and development due to its unique structure and properties

Upstream product

• 3619-22-5 p-toluic hydrazide 
• 503-38-8 trichloromethyl chloroformate 
• 201230-82-2 carbon monoxide 
• 33414-97-0 1-(p-Toluoyl)-2-aethoxycarbonylhydrazin 
• 874-60-2 4-methyl-benzoyl chloride 
• 20605-43-0 phenyl hydrazinecarboxylate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 124-38-9 carbon dioxide 
• 104-87-0 4-methyl-benzaldehyde 
• 1422157-56-9 N′-(chloro-p-tolylmethylene)-tert-butylcarbazate 
• 180462-77-5 tert-butyl-2-[(4-methylphenyl)methylidene]hydrazinecarboxylate 
• 99-94-5 p-Toluic acid 
• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 121649-28-3 2-Oxo-5-p-tolyl-[1,3,4]oxadiazole-3-carboxylic acid N-phenyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazide 
• 83725-82-0 N-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-4-methyl-benzamide 
• 137678-25-2 2-(2-Oxo-5-p-tolyl-[1,3,4]oxadiazol-3-yl)-acetamide 
• 121649-37-4 N-(3,5-Dioxo-1-phenyl-[1,2,4]triazolidin-4-yl)-4-methyl-benzamide 
• 121649-34-1 2-Oxo-5-p-tolyl-[1,3,4]oxadiazole-3-carboxylic acid methyl ester 
• 121649-41-0 3-methyl-5-(p-tolyl)-1,3,4-oxadiazol-2(3H)-one 
• 137678-60-5 N-(2,4-Dioxo-3-{[1-phenyl-meth-(E)-ylidene]-amino}-imidazolidin-1-yl)-4-methyl-benzamide 
• 137678-38-7 N-(3-Butyl-2,4-dioxo-imidazolidin-1-yl)-4-methyl-benzamide 
• 137678-32-1 N-(3-Butyl-2,4-dioxo-imidazolidin-1-yl)-benzamide 
• 137678-53-6 N-Ethyl-2-(2-oxo-5-p-tolyl-[1,3,4]oxadiazol-3-yl)-acetamide 
• 137678-37-6 N-(2,4-Dioxo-3-propyl-imidazolidin-1-yl)-4-methyl-benzamide 
• 137678-36-5 N-(3-Ethyl-2,4-dioxo-imidazolidin-1-yl)-4-methyl-benzamide 
• 137678-52-5 N-Methyl-2-(2-oxo-5-p-tolyl-[1,3,4]oxadiazol-3-yl)-acetamide 
• 137678-56-9 N-(3-Amino-2,4-dioxo-imidazolidin-1-yl)-4-methyl-benzamide 

Relevant articles and documents

Investigation of Masked N-Acyl-N-isocyanates: Support for Oxadiazolones as Blocked N-Isocyanate Precursors

In contrast to carbon-substituted isocyanates that are common building blocks, N-substituted isocyanates remain underdeveloped and reports on their N-acyl derivatives (i. e. amido-isocyanates) are exceedingly rare. Herein, amido-isocyanates were investiga

DMF as Methine Source: Copper-Catalyzed Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles

An unprecedented Cu-catalyzed direct annulation of hydrazides with N,N-dimethylformamide (DMF) was developed, providing an efficient synthesis of valuable 1,3,4-oxadiazoles. This process features the short reaction time and can be safely conducted on gram scale. The reaction also facilitated the convenient synthesis of 1,3,4-oxadiazole-2(3H)-ones. Moreover, the mechanistic studies suggest that the source of CH is from the N-methyl group of DMF. (Figure presented.).

Palladium-catalyzed oxidative O-H/N-H carbonylation of hydrazides: Access to substituted 1,3,4-oxadiazole-2(3 H)-ones

A novel palladium-catalyzed oxidative annulation reaction for the C-O, C-N bond formations is developed. The intramolecular cyclocarbonylation provides an efficient and direct approach for the construction of valuable 1,3,4-oxadiazole-2(3H)-ones and their