83725-79-5

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one is used as a pharmaceutical candidate for its potential antioxidant and antibacterial properties. The strong electron-withdrawing nitro group in its molecule makes it a promising substance for the development of new drugs.
Used in Agrochemical Industry:
5-(2-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one is used as an agrochemical candidate due to its potential antibacterial properties. It can be utilized in the development of new pesticides or other agrochemicals to protect crops from bacterial infections.
Used in Materials Science:
5-(2-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one is used as a building block in the synthesis of more complex organic molecules in materials science. Its unique structural and electronic properties make it valuable for creating new materials with specific properties.
Used in Research Applications:
5-(2-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one is used as a research compound to explore its potential applications in various fields. Its unique properties and reactivity make it an interesting subject for scientific investigations and experiments.

Upstream product

• 75-44-5 phosgene 
• 606-26-8 o-nitrobenzohydrazide 
• 503-38-8 trichloromethyl chloroformate 
• 106728-63-6 2-Nitrobenzaldehyde t-Butoxycarbohydrazone 
• 530-62-1 1,1'-carbonyldiimidazole 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 86601-73-2 5-(2-aminophenyl)-1,3,4-oxadiazol-2(3H)-one 
• 83725-83-1 N-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-2-nitro-benzamide 

Relevant academic research and scientific papers

Substituted phenyl derivatives, their preparation and use

The present invention discloses compounds having the formula wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.

Substituted phenyl derivatives, their preparation and use

The present invention discloses compounds having the formula wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.

Substituted phenyl derivatives, their preparation and use

A compound having the formula (I) or a pharmaceutically acceptable salt thereof where the variables are defined in the specification are useful in the treatment of sickle-cell anemia.

Some 1-Aroyl-4,4-dialkylsemicarbazides and Their Cyclization to Afford 5-Aryl-1,3,4-oxadiazol-2(3H)-ones

Some 1-aroyl-4,4-dialkylsemicarbazides have been prepared by reacting aroyl-hydrazides with dimethyl- or diethyl-carbamoyl chloride.In boiling DMF they lose dimethylamine or diethylamine to give 5-aryl-1,3,4-oxadiazol-2(3H)-ones. - Keywords: 1-Aroyl-4,4-d

1,3,4-Oxadiazolin-2-ones from Carbo-t-butoxyhydrazones

5-Substituted-1,3,4-oxadiazolin-2-ones 2 were synthesized by the oxidation of carbo-t-butoxyhydrazones 1 of aromatic aldehydes with lead tetraacetate or, preferably, iodosobenzene diacetate.In some instances 5-acetoxy-1,3,4-oxadiazoles 3 were obtained along with 2.The oxidation of carboethoxyhydrazones 4 gave 2-ethoxy-1,3,4-oxadiazoles 5.

The Preparation of 5-(2-Aminophenyl)-1,3,4-oxadiazole-2(3H)-one and Its Rearrangement to 3-Amino-2,4(1H,3H)-quinazolinedione

When anthranilic acid hydrazide is reacted with 1,1'-carbonyldiimidazole in THF 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-one (4) is formed.It can also be prepared from 1-o-aminobenzoyl-4,4-dimethylsemicarbazide which eliminates methylamine when boiled with DMF.On heating the 5-(2-aminophenyl)-1,3,4-oxadiazole above its melting point it rearranges to 3-amino-2,4(1H,3H)-quinazolinedione (5). - Keywords: 3,4-Dihydro-1H-1,3,4-benzotriazepine-2,5-dione; Oxadiazoles

Synthesis of Substituted N-(2,4-Dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides and N-(2-Thiono-4-oxo-1,2,3,4-tetrahydroquinazolinyl)benzamides

Substuted N-(2,3-dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides (3a-g) and substituted N-(2-thiono-4-oxo-1,2,3,4-tetrahydroquinazolinyl)benzamides (4a-g) were synthetized in one step from the reaction of methyl anthranilate with 2-aryl-1,3,4-oxadiazolin-5-ones (1a-g) and 2-aryl-1,3,4-oxadiazoline-5-thiones (2a-g), respectively, in m-cresol at 150-160 deg C.Alternative routes leading to the formation of 3a and 4a are also reported.