837408-79-4

Upstream product

• 138402-05-8 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one 
• 837408-69-2 N-(3,4-dimethyl-5-isoxazolyl)-4'-bromomethyl-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide 
• 837408-67-0 N-(3,4-dimethyl-5-isoxazolyl)-4'-formyl-2'-propyl-N-([(2-trimethylsilyl)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide 
• 254745-31-8 4-bromo-3-(1-propen-1-yl)benzonitrile 
• 254745-39-6 4-bromo-3-propylbenzaldehyde 
• 89003-95-2 3-formaldehyde-4-bromobenzonitrile 
• 254745-36-3 4-bromo-3-propylbenzonitrile 

Relevant academic research and scientific papers

Dual angiotensin II and endothelin A receptor antagonists: Synthesis of 2′-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics

In a previous report we demonstrated that merging together key structural elements present in an AT1 receptor antagonist (1, irbesartan) with key structural elements in a biphenylsulfonamide ETA receptor antagonist (2) followed by ad