83763-31-9

Usage

Uses

Used in Pharmaceutical Industry:
1-BENZYL-3-HYDROXY-4-DIMETHOXY-PIPERIDINE is used as a potential antipsychotic agent due to its affinity for dopamine receptors. Its interaction with these receptors may help in the management of psychotic disorders.
Additionally, it is used in Medicinal Chemistry and Drug Design:
1-BENZYL-3-HYDROXY-4-DIMETHOXY-PIPERIDINE serves as a promising candidate for further research and development in the field of medicinal chemistry. Its unique structure and properties may contribute to the design of new drugs with improved efficacy and safety profiles.
Further research is necessary to fully understand the properties and potential uses of 1-benzyl-3-hydroxy-4-dimethoxy-piperidine, including its pharmacological effects, safety, and optimal applications in various therapeutic areas.

InChI:InChI=1/C14H21NO3/c1-17-14(18-2)8-9-15(11-13(14)16)10-12-6-4-3-5-7-12/h3-7,13,16H,8-11H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 124-41-4 sodium methylate 

Downstream Products

• 133341-78-3 1-Benzyl-3-hydroxy-piperidin-4-one O-benzyl-oxime 
• 86717-83-1 4-amino-1-benzylpiperidin-3-ol 
• 1130156-23-8 (±)-tert-butyl 3-hydroxy-4-oxopiperidine-1-carboxylate 
• 1331777-74-2 (3S,4R)-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate 

Relevant academic research and scientific papers

Indirect electrochemical oxidation of piperidin-4-ones mediated by sodium halide-base system

Indirect electrochemical oxidation of 1-N-subsituted piperidin-4-ones in methanol in an undivided cell in the presence of sodium iodide/sodium methoxide system leads to the corresponding α-hydroxyketals in 50-80% substance yield (50-65% current yield). 2,2,6,6-Tetramethylpiperidin-4-one under the same conditions forms a mixture of methyl 2,2,5,5-tetramethyl-3-pyrrolidinecarboxylate and methyl 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylate in 70% substance yield (60-70% current yield) via electrochemically induced Favorskii rearrangement.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

α-Hydroxylation of carbonyls using iodine

The α-hydroxylation of ketones and aldehydes to α-hydroxyketals mediated by iodine under basic conditions in MeOH is described. Enolates generated under the reaction conditions are iodinated and the resulting α-iodocarbonyl is transformed into the hydroxyketal. The use of iodine for this chemistry represents an economical and practical alternative to existing methods for this transformation.

N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

This invention pertains to novel N-aryl-N-[N-substituted 3-alkoxy-4-piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic administration to mammals of such compounds, and pharmaceutical compositions containing such compounds, wherein the novel compounds have the general formula: STR1 including optically active isomeric forms, cis/trans isomeric forms and the pharmaceutically acceptable acid addition salts therof, wherein: R is an aryl group selected from the group consisting of phenyl and substituted phenyl, wherein the substituents on the phenyl group are independently selected from the group consisting of halogen, lower-alkyl, lower-alkoxy, and combinations thereof; R1 is an alkyl group selected from the group consisting of lower-alkyl, lower-alkenyl, and lower-alkoxy lower-alkyl, each alkyl group having from 1 to 6 carbon atoms; R2 is a member selected from the group consisting of phenyl lower-alkyl, thienyl lower-alkyl, pyrazolyl lower-alkyl, tetrazolyl lower-alkyl, 4,5-dihydro-5-oxo-1H-tetrazolyl lower-alkyl, 1,3-dihydro-1,3-dioxo-2H-isoindolyl lower-alkyl, and 2,3-dihydro-2-oxo-1H-benzimidazolyl lower-alkyl; and R3 is a member selected from the group consisting of hydrogen, lower-alkyl and lower-alkyl aryl.

Stereoselective reduction of α-hydroxy oxime ethers: A convenient route to cis-1,2-amino alcohols

Reduction of cyclic α-hydroxyketoximes with borane provides an excellent, high yielding, regio- and stereoselective route to cis-1,2-aminoalcohols.

Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives

Novel N-(3-hydroxy-4-piperidinyl)benzamides and derivatives thereof, said compounds being useful as stimulators of the motility of the gastro-intestinal system.