83802-88-4Relevant academic research and scientific papers
Phase-Vanishing Methodology for Efficient Bromination, Alkylation, Epoxidation, and Oxidation Reactions of Organic Substrates
Jana, Nirmal K.,Verkade, John G.
, p. 3787 - 3790 (2003)
(Matrix presented) In cases where both reactants in a phase-vanishing reaction are less dense than the fluorous phase, an alternative to the U-tube method is to employ a solvent with greater density than the fluorous phase, such as 1,2-dibromoethane. This modification has been successfully applied to the methylation of a phenol derivative with dimethyl sulfate and to the m-CPBA-induced epoxidation of alkenes, N-oxide formation from nitrogen-containing compounds, and S-oxide or sulfone formation from organic sulfides.
Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder
-
, (2009/01/24)
The present invention provides preventive and/or therapeutic agents for either one, or both, of a diabetic vascular disorder and a diabetic respiratory disorder comprising, as an active ingredient, a cyclohexenone long chain alcohol compound represented b
THERAPEUTIC AGENT FOR SENSORY ABNORMALITY
-
Page/Page column 12, (2008/06/13)
The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branc
Cascade radical carbonylations leading to 3-substituted cyclohexanones
Uenoyama, Yoshitaka,Fukuyama, Takahide,Ryu, Ilhyong
, p. 2342 - 2344 (2007/10/03)
Tin radical mediated [5+1]-annulation methods leading to 3-substituted cyclohexanones were investigated. Cyclohexanones having a quaternary center at the 3-position were synthesized in good yields by allyltin-mediated three- and four-component cascade rea
Cyclohexenone long-chain alcohol and medicament containing same
-
, (2008/06/13)
Described is a cyclohexenone long-chain alcohol represented by the formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a C10-18 alkylene or alkenylene group. The cyclohexanone long-chain alco
Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators
Luu, Bang,Gonzalez De Aguilar, Jose-Luis,Girlanda-Junges, Celine
, p. 1439 - 1460 (2007/10/03)
Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
Facile nucleophilic substitution of 3-tert-butyldimethylsilyloxyalk-2-enylphosphonium salts
Lee, Phil Ho,Cho, Minkyoung,Han, In-Sup,Kim, Sunggak
, p. 6975 - 6978 (2007/10/03)
Phosphoniosilylation of a,β-enones with TBSOTf and triphenylphosphine at 0 °C affords 3-tert-butyldimethylsilyloxyalk-2-enylphosphonium salts, which undergo facile nucleophilic substitution with various nucleophiles to give 3-substituted silyl enol ethers
Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship
Girlanda-Junges, Celine,Keyling-Bilger, Florence,Schmitt, Gaby,Luu, Bang
, p. 7735 - 7748 (2007/10/03)
Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.
