196790-46-2Relevant academic research and scientific papers
Lipase-mediated diastereoselective and enantioselective acetylations of 3-substituted cyclohexanols
Tanikaga, Rikuhei,Morita, Akira
, p. 635 - 638 (2007/10/03)
Lipase-mediated acetylation of four diastereomeric and enantiomeric isomers of 3-substituted cyclohexanols 2 has led to an efficient resolution to provide a single stereoisomer, (1R,3S)-cyclohexyl acetate (1R,3S)-3 in a high enantiomeric excess.
Baker's yeast-mediated reduction of cyclohexanones containing a nitro or a sulfonyl group at C-3
Tanikaga, Rikuhei,Obata, Yukinori,Kawamoto, Ken-Ichi
, p. 3101 - 3106 (2007/10/03)
Baker's yeast-mediated reduction of 3-(nitromethyl)-, 3-(phenylsulfonyl)-, and 3-[(phenylsulfonyl)methyl]-cyclohexanones 1a,c,d led to the delivery of a hydride to the re-face of the prochiral ketones to provide cyclohexanols (1S,3S)- and (1S,3R)-2a,c,d with high enantioselectivities in good yields. The remote nitro and sulfonyl groups, in contrast to alkyl and sulfenyl groups, may play an important role in binding to an enzyme.
