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Usage

Uses

Used in Dietary Supplements:
Choline dihydrogen phosphate is used as a dietary supplement for its potential health benefits, including support for liver function, memory improvement, and nerve signaling enhancement.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, choline dihydrogen phosphate is used as a component in various medications, taking advantage of its role in bodily functions and metabolism.
Used as a Chemical Intermediate:
Choline dihydrogen phosphate also serves as a chemical intermediate in the synthesis of other compounds, highlighting its utility in the chemical and pharmaceutical sectors for the creation of new products and treatments.

InChI:InChI=1/C5H14NO.H3O4P/c1-6(2,3)4-5-7;1-5(2,3)4/h7H,4-5H2,1-3H3;(H3,1,2,3,4)/q+1;/p-3

Upstream product

• 67-48-1 choline chloride 
• 123-41-1 cholin hydroxide 
• 86119-84-8 phosphoric acid 
• 78-73-9 cholinium hydrogen carbonate 
• 1927-06-6 choline bromide 

Relevant academic research and scientific papers

Ionic liquid as an efficient modulator on artificial enzyme system: Toward the realization of high-temperature catalytic reactions

Herein, with the aid of ionic liquid, we demonstrate for the first time that highly stable Au/SiO2 hetero-nanocomposites can serve as a robust and recyclable peroxidase mimic for realizing high-temperature catalytic reactions. Our findings pave the way to use nanomaterials for the design and development of efficient biomimetic catalysts and, more significantly, to apply ionic liquid as a positive modulator in catalytic reactions.

Self polymerising ionic liquid gel

A novel self-polymerised ionic liquid (IL) gel was prepared at room temperature (RT), without light or heat or addition of initiator, using a new IL, choline formate (CF), and 2-hydroxyethyl methacrylate (HEMA). The Royal Society of Chemistry 2009.

Cleaner enzymatic production of biodiesel with easy separation procedures triggered by a biocompatible hydrophilic ionic liquid

The great challenges of modern industry and the environment make it important to develop sustainable energy resources with low cost. In this work, a cleaner enzymatic procedure for biodiesel production was developed through the utilization of a biocompatible and hydrophilic ionic liquid [Choline][H2PO4]. This ionic liquid can be synthesized from cheap raw materials through simple neutralization procedures, and it has been proved to be well biocompatible. The utilization of this ionic liquid in Novozym 435 catalyzed biodiesel production makes the reaction and work-up procedures very simple, because its hydrophilicity can lead to the implementation of a pseudo homogeneous reaction and then heterogeneous separation. Various oil resources such as triolein, sunflower oil and castor oil can all be converted to biodiesels with high yields. After the completion of reaction, both the ionic liquid and Novozym 435 can be recycled and reutilized for at least five cycles without a significant activity decrease. In addition, this reaction system can be conveniently scaled up to the multi-gram level with high efficiency and feasible separation. Overall, the above mentioned benefits make this ionic liquid based enzymatic system cleaner for the production of biodiesel and promising for further industrial applications.

An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes

Development of new chemical processes with simplified reaction systems and work-up procedures is a challenging task. Although ionic liquids are a class of potential multifunctional compounds to simplify traditional chemical processes, their rational design is difficult due to complex interactions. In this work, a proof-of-concept strategy has been proposed to achieve an integration of high-throughput preparation of ionic liquids and in situ screening of their reaction-promoting performance in 96-well plates. The integrated approach then enables a facile identification of optimal ionic liquids from a 400-ionic liquid candidate pool to act as the solvent, the catalyst and the separating assistant, simultaneously, for carbonyl-azide cycloaddition reactions. Merits of the ionic liquids-based processes have been demonstrated not only in the convenient and efficient synthesis of 1,2,3-triazolyl compounds but also in the discovery of a new reaction for the chemical post-modification of free peptides.

BIOCATALYST SOLVENT USING IONIC LIQUID, AND BIOCATALYST SOLUTION CONTAINING THE SOLVENT AND BIOCATALYST

PROBLEM TO BE SOLVED: To provide: a biocatalyst solvent that can be stored for a long period of time and that can dissolve a high concentration of a biocatalyst from low temperatures to high temperatures while retaining the activity of the biocatalyst; and a biocatalyst solution using the biocatalyst solvent. SOLUTION: The biocatalyst solvent is composed of an ionic liquid containing anions and quaternary ammonium cations represented by the following formula (1), where each Ra independently represents: a hydroxyalkyl group which has at least one hydroxyl group, in which the alkyl moiety is in a C1-10 straight-chained or branched state, and in which the alkyl moiety may contain an oxygen atom; a carboxyalkyl group which has at least one carboxy group, in which the alkyl moiety is in a C1-10 straight-chained or branched state, and in which the alkyl moiety may contain an oxygen atom; or a hydroxy-carboxyalkyl group which has at least one each of a hydroxyl group and a carboxy group, in which the alkyl moiety is in a C1-10 straight-chained or branched state, and in which the alkyl moiety may contain an oxygen atom and where each Rb independently represents a hydrogen atom or a C1-5 straight-chained or branched alkyl group. n represents an integer of 1-4. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Free-radical polymerization of itaconic acid in the presence of choline salts: Mechanism of persulfate decomposition

Kinetics of decomposition of persulfate activated by choline in aqueous solution has been studied. Additionally, the products of choline degradation were analyzed by 1H NMR spectroscopy, and betaine aldehyde was identified as the main oxidation product. Thus, radical-chain redox mechanism is postulated to explain experimental results. The mechanism was successfully verified using kinetic modeling approach. Moreover, it was found that due to formation of complex of itaconic acid and choline chloride, the salt solubility of the acid in water was increased. Finally, free-radical polymerization of itaconic acid initiated by persulfate in aqueous solution of the choline salt yielded poly(itaconic acid) with higher molecular weight and increased polydispersity.

Fast and efficient extraction of DNA from meat and meat derived products using aqueous ionic liquid buffer systems

A short, simple and inexpensive process for the extraction of DNA from meat was developed investigating a set of 20 ionic liquids including imidazolium, choline and guanidinium derivatives in combination with aqueous buffer systems. The environmentally benign ionic liquid choline hexanoate-phosphate buffer mixture gave the most promising results and DNA was extracted within 20 minutes from different types of meats, such as beef, chicken, pork and horse in significantly higher yields compared to the pure phosphate buffer. The influence of the ionic liquid on the amplification process during the PCR was further investigated, showing an inhibitory effect with increasing chain length of the ionic liquid and with higher ionic liquid concentrations. Additionally, extracted DNA was stable for 20 days when stored at room temperature in aqueous ionic liquid-buffer mixtures.

One-pot synthesis of 3,4-dihydro-2(H)-pyrimidinones catalyzed by reusable acidic choline-based ionic liquids

A series of choline-based ionic liquids (CIL) have been synthesized in this work. The results suggested that both the cations and the anions have significant influences on their properties such as thermostabilities, acidities and their performances for the synthesis of 3,4-dihydro-2(H)-pyrimidinones. The optimized catalytic system based on the CIL [DMEA][HSO4] for the Biginelli reactions benefits from the wide substrates tolerance, benign reaction conditions, easy work-up procedures, and the feasible reusability of the ionic liquid. Graphical Abstract: The thermostabilities, acidities, and the catalytic activities for the Biginelli reactions are all follows the sequence of [DMEA][HSO4] > [Choline] [HSO4] > [DMEA][H 2PO4] > [Choline] [H2PO4][Figure not available: see fulltext.].

Enzymatic activity and thermal stability of metallo proteins in hydrated ionic liquids

Hydrated choline dihydrogen phosphate (Hy[ch][dhp]) containing 30 wt% water was investigated as a novel protein solvent. The Hy[ch][dhp] dissolved some metallo proteins (cytochrome c, peroxidase, ascorbate oxidase, azurin, pseudoazurin and fructose dehydrogenase) without any modification. These proteins retained the surroundings of the active site after dissolution in Hy[ch][dhp]. Some metallo proteins were found to retain their activity in the Hy[ch][dhp].

Biocompatibility of choline salts as crosslinking agents for collagen based biomaterials

A series of novel choline based salts, some of which can be described as ionic liquids, are prepared and evaluated for their biocompatibility; when combined with collagenous biomaterials they exhibit good cell viability and adhesion properties as required for biomedical implant applications.