51856-79-2

Basic information

• Product Name: Methyl 1-methyl-2-pyrroleacetate
• Synonyms: 1-METHYLPYRROLE-2-ACETIC ACID METHYL ESTER;LABOTEST-BB LT00455212;METHYL 1-METHYLPYRROLE-2-ACETATE;METHYL,1-METHYL PYRROLEACETATE;METHYL 1-METHYL-2-PYRROLEACETATE;Methyl (1-methyl-1H-pyrrol-2-yl)acetate;Methyl 1-methyl-1H-pyrrole-2-acetate;Methyl(1-methyl-2-pyrrolyl)acetate
• CAS NO: 51856-79-2
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.18
• EINECS: 257-478-0
• Mol File: 51856-79-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 80-85 °C2 mm Hg(lit.)
• Flash Point: 224 °F
• Appearance: Clear orange to slightly brown liquid
• Density: 1.064 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0348mmHg at 25°C
• Refractive Index: n20/D 1.501(lit.)
• Storage Temp.: 2-8°C
• Solubility: 8.3 g/L (20°C)
• PKA: -3.42±0.70(Predicted)
• Water Solubility: 8.3 g/L (20 ºC)
• CAS DataBase Reference: Methyl 1-methyl-2-pyrroleacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-methyl-2-pyrroleacetate(51856-79-2)
• EPA Substance Registry System: Methyl 1-methyl-2-pyrroleacetate(51856-79-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 51856-79-2(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR ORANGE TO SLIGHTLY BROWN LIQUID

InChI:InChI=1/C8H11NO2/c1-9-5-3-4-7(9)6-8(10)11-2/h3-5H,6H2,1-2H3

Upstream product

• 71290-64-7 1-methyl-2-(2',2',2'-trichloro-1'-hydroxyethyl)pyrrole 
• 74-88-4 methyl iodide 
• 83846-84-8 C₉H₁₁NO₄ 
• 83863-74-5 2-(carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid 
• 21898-43-1 2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetic acid 
• 67-56-1 methanol 
• 21898-59-9 1-methylpyrrole-2-acetic acid 
• 96-54-8 N-Methylpyrrole 
• 21898-44-2 (1-methyl-pyrrol-2-yl)-oxo-acetic acid methyl ester 
• 6773-29-1 dimethyl diazomalonate 
• 5199-50-8 methyl 2-iodoacetate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 80096-44-2 (5-benzoyl-1-methyl-1H-pyrrol-2-yl)acetic acid methyl ester 
• 26235-66-5 methyl 2-<1-methyl-5-(p-chlorobenzoyl)-pyrrrole>acetate 
• 26171-24-4 methyl 1-methyl-5-(4-methoxybenzoyl)pyrrole-2-acetate 
• 179384-48-6 [5-(4-acetylamino-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acetic acid methyl ester 
• 179382-76-4 [5-(4-amino-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acetic acid methyl ester 
• 667871-03-6 (1-methyl-5-phenylacetyl-1H-pyrrol-2-yl)-acetic acid methyl ester 
• 21898-59-9 1-methylpyrrole-2-acetic acid 
• 33369-52-7 methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate 
• 35711-34-3 tolmetin sodium 
• 200496-24-8 Methyl 2-(1-methylpyrrol-2-yl)-2-(4-nitrophenyl)acetate 
• 26171-23-3 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid 
• 1207070-75-4 (2-{2-[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]acetylamio}-acetylamino)acetic acid 2-methoxy-phenyl ester 
• 1207070-76-5 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester 
• 93962-13-1 C₁₈H₂₀N₂O₄ 

Relevant articles and documents

Synthetic method of non-steroidal antiinflammatory drug pain killing

The invention discloses a synthesis method of non-steroidal anti-inflammatory drug tolmetin. The methodcomprises the following steps: sequentially preparing a sulfuric acid-containing acetonedicarboxylic acid crude product, 2-(2-acetoxy)-1-methyl-1H-pyrrole-3-formic acid and 2-(2-alkyl acetate)-1-methyl-1H-pyrrole-3-formic acid by taking citric acid or citric acid monohydrate as a raw material; and carrying out decarboxylation, acylation, hydrolysis and acidification to obtain tolmetin. The synthetic method provided by the invention overcomes the defect that the existing tolmetin preparation process depends on N-methylpyrrole, and is a low-cost, low-pollution and high-yield synthetic method of non-steroidal anti-inflammatory drug tolmetin.

Synthesis, antimicrobial, and anti-inflammatory activities of acetamido pyrrolyl azoles

The acetamido pyrrolyl oxazoles/thiazoles/imidazoles were prepared and tested for their antimicrobial and anti-inflammatory activities. The nitro substituted acetamido pyrrolyl thiazole (11f) and pyrrolyl imidazole (12f) exhibited promising antibacterial activity against K. pneumoniae. The compound 12f showed good antifungal activity against P. chrysogenum. The methoxy acetamido pyrrolyl oxazole (10c) displayed potential anti-inflammatory activity.

Friedel - Crafts acylation of pyrroles and indoles using 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) as a nucleophilic catalyst

1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) has been shown to be an effective catalyst for the regioselective Friedel - Crafts C-acylation of pyrroles and indoles in high yields. A detailed mechanistic study implies that DBN is acting as a nucleophilic organocatalyst, with the X-ray crystal structure of a key N-acyl-amidine intermediate having been determined for the first time.