83948-24-7

Upstream product

• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 83948-25-8 4-amino-4-(6-bromo-3,4-dimethoxyphenyl)-1-butene 
• 18034-03-2 nornitidine 

Relevant academic research and scientific papers

Formal synthesis of nitidine and NK109 via palladium-catalyzed domino direct arylation/N-arylation of aryl triflates

The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically interesting benzo

Preparation of Primary Amines and 2-Azetidinones via N-Trimethylsilyl Imines

Nonenolizable aldehydes react with lithium bis(trimethylsilyl)amide at ambient temperatures to afford solutions of N-trimethylsilyl aldimines.Treatment of these solutions with Grignard reagents or alkyllithiums followed by an aqueous workup gives primary amines in moderate to excellent yields.Treatment of N-trimethylsilyl aldimines with ester enolates provides an expedient route to 1-unsubstituted 2-azetidinones.