839677-97-3

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 839677-94-0 (2R,5R)-5-(4-Bromo-benzyl)-2-tert-butyl-3-(4-chloro-phenyl)-5-methyl-1-(2,2,2-trifluoro-acetyl)-imidazolidin-4-one 

Downstream Products

• 839678-00-1 {[2-(4-bromo-phenyl)-1-(4-chloro-phenylcarbamoyl)-1-methyl-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

A practical synthesis of highly functionalized fused 1,6-dihydroimidazo-[1, 2-a]imidazole-2,5-diones, key intermediates for LFA-1 inhibitors

An alternative and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A key feature of this process involved a transformation of thioureas 14 to acyclic guanidine derivatives 9 followed by intramolecular cyclizati