839677-94-0Relevant academic research and scientific papers
A practical synthesis of highly functionalized fused 1,6-dihydroimidazo-[1, 2-a]imidazole-2,5-diones, key intermediates for LFA-1 inhibitors
Wang, Xiao-Jun,Xu, Yibo,Zhang, Li,Krishnamurthy, Dhileepkumar,Nummy, Laurence,Farina, Vittorio,Senanayake, Chris H.
, p. 2800 - 2802 (2004)
An alternative and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A key feature of this process involved a transformation of thioureas 14 to acyclic guanidine derivatives 9 followed by intramolecular cyclizati
