839712-89-9Relevant academic research and scientific papers
A convenient synthesis of new purinyl-homo-carbonucleosides on a cyclopentane ring fused with pyridazine
Caamano, Olga,Gomez, Generosa,Fernandez, Franco,Garcia, Marcos Daniel,Garcia-Mera, Xerardo,De Clercq, Eric
, p. 2855 - 2862 (2004)
The new purinyl homo-carbonucleosides 10 and 17a were prepared from 1,4-diphenyl-5,8-dihydro-5,8-methanophthalazine by one-pot ozonolysis and reductive cleavage, followed by monoprotection with an Ac or TBDMS group, mesylation of the resulting diol and replacement of the mesyl group with 6-chloropurine in the presence of NaH and 18-crown-6 ether. Homo- carbonucleosides 12 and 13 were then obtained from 10 by substitution of the chlorine in purine position 6. Compounds 17b and 19 were obtained from 17a in the same way.
Synthesis of cyclopenta[d]pyridazinediol precursors of carbanucleosides
Perez-Castro, Isabel,Caamano, Olga,Garcia, Marcos D.,Gomez, Generosa,Fernandez, Franco,Ferreira, Joana,Lopez, Carmen
, p. 2621 - 2626 (2007)
The hemiprotected diols 7 and 8, which are prospective precursors of carbanucleosides of this family, were prepared from the mesylates of the corresponding higher homologues by elimination of the mesyloxy group using l,8-diazabicyclo[5.4.0]undec-7-ene fol
Design, synthesis, and evaluation of antineoplastic activity of novel carbocyclic nucleosides
Helguera, Aliuska M.,Rodriguez-Borges,Caamano, Olga,Garcia-Mera, Xerardo,Gonzalez, Maykel Perez,Cordeiro, M. Natalia D.S.
experimental part, p. 213 - 231 (2010/10/02)
Cancer is the leading cause of death among men and women under age 85. Every year, millions of individuals are diagnosed with cancer. But finding new drugs is a complex, expensive, and very time-consuming task. Over the past decade, the cancer research co
