839712-89-9

Basic information

• Product Name: 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-
• CAS NO: 839712-89-9
• Molecular Formula: C27H32N2OSi
• Molecular Weight: 428.649
• Mol File: 839712-89-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-(839712-89-9)
• EPA Substance Registry System: 5H-Cyclopenta[d]pyridazine, 5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-7-methylene- 1,4-diphenyl-(839712-89-9)

Safety Data

• Hazardous Substances Data: 839712-89-9(Hazardous Substances Data)

Upstream product

• 87-42-3 6-chloropurine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 10310-21-1 2-amino-6-chloropurine 

Relevant articles and documents

A convenient synthesis of new purinyl-homo-carbonucleosides on a cyclopentane ring fused with pyridazine

The new purinyl homo-carbonucleosides 10 and 17a were prepared from 1,4-diphenyl-5,8-dihydro-5,8-methanophthalazine by one-pot ozonolysis and reductive cleavage, followed by monoprotection with an Ac or TBDMS group, mesylation of the resulting diol and replacement of the mesyl group with 6-chloropurine in the presence of NaH and 18-crown-6 ether. Homo- carbonucleosides 12 and 13 were then obtained from 10 by substitution of the chlorine in purine position 6. Compounds 17b and 19 were obtained from 17a in the same way.

Design, synthesis, and evaluation of antineoplastic activity of novel carbocyclic nucleosides

Cancer is the leading cause of death among men and women under age 85. Every year, millions of individuals are diagnosed with cancer. But finding new drugs is a complex, expensive, and very time-consuming task. Over the past decade, the cancer research co