84010-78-6

Upstream product

• 28143-91-1 (1S,2S)-2-amino-1-phenyl-1,3-diol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 92686-75-4 N'-(S,S)BISPAD-N,N-dimethylformamidine 
• 132015-07-7 1-<(1'S,2'S)-1'-phenyl-1',3'-dihydroxy-2'-propyl>-3(S)-phthalimido-4(R)-styryl-azetidin-2-one 
• 131895-40-4 1-<(1'S,2'S)-1'-phenyl-1',3'-dihydroxy-2'-propyl>-3(R)-phthalimido-4(S)-styryl-azetidin-2-one 
• 191418-22-1 1-(3'-phenyl-propen-3'-on-2'-yl)-3(R)-phthalimido-4(S)-styryl-azetidin-2-one 
• 191418-21-0 1-((1'S,2'S)-1'-phenyl-1'-hydroxy-3'-acetoxy-2'-propyl)-3(R)-phthalimido-4(S)-styryl-azetidin-2-one 
• 84010-77-5 [1-[(S)-1-(4-Chloro-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]-meth-(E)-ylidene]-((R)-2-phenyl-2-trimethylsilanyloxy-1-trimethylsilanyloxymethyl-ethyl)-amine 
• 57680-87-2 (1R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 57680-86-1 (1S)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

2-amino-1-phenyl-propan-1,3-diol as chiral auxiliary. Application in the synthesis of cis 3-phthalimido-4-styryl-2-azetidinones

3,4-cis3,4-cis-1-N-(1'-phenyl-1',3'-dihydroxy-2'-propyl)-3-phthalimido-4 -styrylazetidinones were obtained in optically pure form by chiral Staudinger reaction. The cis-α/β-ratio could be influenced by the protective groups of the diol moiety. Removal of the chiral auxiliarity could be accomplished by direct oxidation, or by previous double bond formation, thus the 2-amino-1-phenyl-propan-1,3-diol can be regarded to a generally useful chiral auxiliary.

ENANTIOSELECTIVE ALKYLATION OF α-AMINO CARBANIONSTHE SYNTHESIS OF (S)-1-ALKYL-1,2,3,4 TETRAHYDROISOQUINOLINES

A series of chiral amino alcohols transformed into the formamidine derivative of 1,2,3,4-tetrahydroisoquinolines were evaluated as chiral dipole-stabilized anions.Alkylation with alkyl halides provided the 1-alkyl-1,2,3,4-tetrahydroisoquinolines in both e