84016-45-5Relevant academic research and scientific papers
SHORT-STEP SYNTHESIS OF NAPROXENE. REGIOSELECTIVE FRIEDEL-CRAFTS REACTION OF 2-CHLORO-2-ALKYLTHIO-PROPIONATES
Arai, Kazutaka,Ohara, Yoshio,Iizumi, Toyoko,Takaguwa, Yasuo
, p. 1531 - 1534 (1983)
2-(6-Methoxy-2-naphthyl)propionic acid (4), dl-naproxen, was conveniently prepared by the regioselective reaction of alkyl 2-chloro-2-alkylthio-propionate (2) and 2-methoxynaphtalene (1) in good yield.This Friedel-Crafts reaction was found to be applicable to the other electron-rich aromatics.
