Tetrahedron Letters p. 1531 - 1534 (1983)
Update date:2022-08-04
Topics:
Arai, Kazutaka
Ohara, Yoshio
Iizumi, Toyoko
Takaguwa, Yasuo
2-(6-Methoxy-2-naphthyl)propionic acid (4), dl-naproxen, was conveniently prepared by the regioselective reaction of alkyl 2-chloro-2-alkylthio-propionate (2) and 2-methoxynaphtalene (1) in good yield.This Friedel-Crafts reaction was found to be applicable to the other electron-rich aromatics.
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Doi:10.1016/j.tetlet.2005.05.076
(2005)Doi:10.1002/hlca.19830660121
(1983)Doi:10.1021/ic050385s
(2005)Doi:10.1016/j.tet.2005.06.017
(2005)Doi:10.1021/jo00166a042
(1983)Doi:10.3987/COM-04-10287
(2005)
