SHORT-STEP SYNTHESIS OF NAPROXENE. REGIOSELECTIVE FRIEDEL-CRAFTS REACTION OF 2-CHLORO-2-ALKYLTHIO-PROPIONATES

DOI: 10.1016/S0040-4039(00)81701-3

Source and publish data:

Tetrahedron Letters p. 1531 - 1534 (1983)

Update date:2022-08-04

Topics:

Authors:

Arai, Kazutaka

Ohara, Yoshio

Iizumi, Toyoko

Takaguwa, Yasuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)81701-3

2-(6-Methoxy-2-naphthyl)propionic acid (4), dl-naproxen, was conveniently prepared by the regioselective reaction of alkyl 2-chloro-2-alkylthio-propionate (2) and 2-methoxynaphtalene (1) in good yield.This Friedel-Crafts reaction was found to be applicable to the other electron-rich aromatics.

Full text of DOI:10.1016/S0040-4039(00)81701-3

Products guided by the article

Product name:2-Ethylsulfanyl-2-(4-methoxy-phenyl)-propionic acid ethyl ester

Cas No:84016-45-5

R&D Labs maybe for 84016-45-5

LinHai Cina Chemical Co., LTD.

Contact:0576-85580989

Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Chemsky（shanghai）International Co.,Ltd.

Contact:0

Address:0
Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
Yangling Ciyuan biotech Co., Ltd.

Contact:86-15802970736

Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District

Relevant to this article

Palladium-catalyzed allylic alkylation of optically active α-alkenyl-α-acyloxytrialkylsilane

Doi:10.1016/j.tetlet.2005.05.076
(2005)
Structural and configurational dependence of the sensory process in steroids

Doi:10.1002/hlca.19830660121
(1983)
Efficient red-emitting cyclometaiated iridium(III) complexes containing lepidine-based ligands

Doi:10.1021/ic050385s
(2005)
Non-biaryl atropisomers derived from carbohydrates. Part 3: Rotational isomerism of sterically hindered heteroaryl imidazolidine-2-ones and 2-thiones

Doi:10.1016/j.tet.2005.06.017
(2005)
Studies on the Oxidation of Imino Ethers

Doi:10.1021/jo00166a042
(1983)
Absolute stereo-structure of kendarimide A, a novelMDR modulator, from a marine sponge

Doi:10.3987/COM-04-10287
(2005)

Article Doi