84028-53-5Relevant academic research and scientific papers
An alternative approach to the synthesis of the three fragments of anachelin H
Gamba-Sánchez, Diego,Garzón-Posse, Fabián,Prunet, Jo?lle
, p. 2702 - 2715 (2020)
The synthesis of the fully protected peptide, polyketide and alkaloid fragments of anachelin H is presented. The peptide fragment was prepared using a liquid phase peptide synthesis; the polyketide fragment was synthetized using a cross metathesis and an intramolecular oxa-Michael reaction as the key steps to introduce the desired stereochemistry; finally, the alkaloid fragment was obtained by an oxidative cyclization of a catechol derivative using potassium ferricyanide. The synthesis of all fragments was based on the use of natural amino acids as sources of asymmetry. The independent synthesis of the three fragments should allow more efficient biological studies on the fragments instead of the whole natural product. Experiments to illustrate the coupling of fragments and the effectiveness of the convergent strategy are also described.
Structural Reassignment and Absolute Stereochemistry of Madurastatin C1 (MBJ-0034) and the Related Aziridine Siderophores: Madurastatins A1, B1, and MBJ-0035
Tyler, Andrew R.,Mosaei, Hamed,Morton, Stephanie,Waddell, Paul G.,Wills, Corinne,McFarlane, William,Gray, Joe,Goodfellow, Michael,Errington, Jeff,Allenby, Nick,Zenkin, Nikolay,Hall, Michael J.
supporting information, p. 1558 - 1562 (2017/05/31)
The madurastatins are pentapeptide siderophores originally described as containing an unusual salicylate-capped N-terminal aziridine ring. Isolation of madurastatin C1 (1) (also designated MBJ-0034), from Actinomadura sp. DEM31376 (itself isolated from a
Total Synthesis of a Mycobactin: Mycobactin S2
Maurer, Peter J.,Miller, Marvin J.
, p. 240 - 245 (2007/10/02)
The synthesis of mycobactin S2, 1 (R2, R3, R5 = H, R1, R4 = CH3) is described.Mycobactin S2 is identical with natural mycobactin S except that the long hydrocarbon chain, R1, replaced by a
