84034-75-3

Usage

Uses

Used in Organic Synthesis:
4-NITROPHENYL HEPTA-O-ACETYL-BETA-LACTOS is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure and reactivity make it a versatile building block in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Analytical Chemistry:
4-NITROPHENYL HEPTA-O-ACETYL-BETA-LACTOS is also used as a substrate in enzymatic assays, particularly for the study of glycosidase enzymes. 4-NITROPHENYL HEPTA-O-ACETYL-BETA-LACTOS serves as a colorimetric indicator, allowing researchers to monitor enzyme activity and kinetics through the release of the yellow-colored 4-nitrophenol upon enzymatic cleavage.
Used in Research and Development:
In the field of research and development, 4-NITROPHENYL HEPTA-O-ACETYL-BETA-LACTOS is employed as a model compound to investigate various chemical reactions and mechanisms. Its reactivity and structural features make it an ideal candidate for probing the efficiency and selectivity of different synthetic routes and methodologies.
Used in Pharmaceutical Industry:
4-NITROPHENYL HEPTA-O-ACETYL-BETA-LACTOS is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly those targeting carbohydrate-based drug discovery. Its unique structure allows for the development of novel therapeutic agents with potential applications in the treatment of various diseases and conditions.
Used in Material Science:
In the field of material science, 4-NITROPHENYL HEPTA-O-ACETYL-BETA-LACTOS is utilized in the development of functional materials with specific properties. Its ability to form complexes and interact with other molecules makes it a promising candidate for the creation of advanced materials with applications in sensors, catalysts, and other high-tech devices.

Upstream product

• 100-02-7 4-nitro-phenol 
• 3616-19-1 1',2',3',6',2,3,4,6-octa-O-acetyl-β-D-lactose 
• 824-78-2 4-nitrophenol sodium salt 
• 5965-66-2 LACTOSE 
• 70223-97-1 2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1->4)-2,3,6-tri-O-acetyl-β-D-glucopyranosyl bromide 
• 83-87-4 D-glucose pentaacetate 
• 2280-44-6 D-Glucose 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 4753-07-5 2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide 
• 3616-19-1 lactose octaacetate 

Downstream Products

• 4419-94-7 4-nitrophenyl β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside 
• 135253-84-8 4-aminophenyl-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1→4)-2,3,6-tetra-O-acetyl-β-D-glucopyranoside 
• 1427462-38-1 5-(-N-(p-O-(2,3,6,2,3,4,6-Hepta-O-acetyl-β-lactosyl)phenyl)-aminocarbonyl)-2,2'-bipyridine 
• 1427462-42-7 5-(-N-(p-O-(β-lactosyl)phenyl)aminocarbonyl)-2,2'-bipyridine 
• 1319112-77-0 p-(4-oxopentanamido)-phenyl β-D-lactose 
• 17691-02-0 p-Aminophenyl 4-O-(β-D-galactopyranosyl)-β-D-glucopyranoside 
• 135253-86-0 Acetic acid (2S,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-2-(4-acryloylamino-phenoxy)-5-((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yl ester 
• 135253-89-3 N-{4-[(2S,3R,4R,5S,6R)-3,4-Dihydroxy-6-hydroxymethyl-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-phenyl}-acrylamide 

Relevant academic research and scientific papers

Glycosylated lanthanide cyclen complexes as luminescent probes for monitoring glycosidase enzyme activity

The development of synthetic chemical probes for the detection of enzymes is extremely important for biological, medicinal, and industrial applications. Here we report the synthesis of an array of novel glycosylated Tb(iii) complexes, their photophysical properties in solution, and their ability to function as luminescent probes for observing glycosidase enzyme activity in real time. Our initial studies into the application of these complexes for the detection of the Concanavalin A (ConA) lectin is also reported, highlighting the broad scope of these novel chemical probes.

BEVERAGE DISPENSING EQUIPMENT

Apparatus and methods for reducing biofouling in drink such as beer dispensing equipment are described.

Hexavalent glycoclusters having tris-bipyridine ferrous complex cores as minimum combinatorial libraries for probing carbohydrate–carbohydrate interactions

2,2′-Bipyridines having two lactoside- or maltoside-appendages were prepared and then, complexed with ferrous ion to afford the corresponding tris-bipyridine ferrous complexes presenting hexavalent lactoside/maltoside clusters. Each of these complexes pro

Synthesis and inhibitory activity evaluation of 2,6-disubstituted purine derivatives

A series of novel 2,6-disubstituted purine derivatives were designed and synthesized from 2,6-dichloropurine. The structures of target compounds were determined by 1H-NMR, 13C-NMR, and HRMS. The synthesized compounds were evaluated for their inhibitory activities against lung cancer cell lines of A549 and liver cancer cell lines of Bel-7402. 2-(4-Benzyloxy-phenylamino)-6-(cyclohexylamino)purine(3), 2-(4-chloro-phenylamino)-6-(n-butylamino)purine (5), 2-(4-morpholinoamino)-6-(4-hydroxy-phenylamino)purine (9), and 2-(4-O-galactosyl-phenylamino)-6-(cyclohexylamino)purine (12) exhibited moderate inhibitory activity.

Glycosylated tris-bipyridine ferrous complexes to provide dynamic combinatorial libraries for probing carbohydrate-carbohydrate interactions

2,2-Bipyridines having β-lactoside, β-d-glucoside, β-d-galactoside, and N-acetyl-β-d-glucosaminide were prepared and then, complexed with ferrous ion to afford trivalent glycoclusters having tris-bipyridine ferrous complex cores. Each glycocluster provides a dynamic combinatorial library composed of four diastereomeric stereoisomers (Δmer, Δfac, Λmer, and Λfac) whose ratios depend on their relative stabilities. CD spectral analyses of these glycoclusters showed that various cations (Na+, Mg2+, K+ or Ca2+) enriched Δ-forms of the glycocluster having β-lactosides and N-acetyl-β-d-glucosaminides possibly by cations-induced intramolecular carbohydrate-carbohydrate interactions.

Glycosynthase with broad substrate specificity-an efficient biocatalyst for the construction of oligosaccharide library

A versatile glycosynthase (TnG-E338A) with strikingly broad substrate scope has been developed from Thermus nonproteolyticus β-glycosidase (TnG) by using site-directed mutagenesis. The practical utility of this biocatalyst has been demonstrated by the facile generation of a small library containing various oligosaccharides and a steroidal glycoside (total 25 compounds) in up to 100 % isolated yield. Moreover, an array of eight gluco-oligosaccharides has been readily synthesized by the enzyme in a one-pot, parallel reaction, which highlights its potential in the combinatorial construction of a carbohydrate library that will assist glycomic and glycotherapeutic research. Significantly, the enzyme provides a means by which glycosynthase technology may be extended to combinatorial chemistry.

Solvent-free mechanochemical synthesis of aryl glycosides

Aryl glycosides have been prepared from a range of readily available glycosyl halides by a solvent-free mechanochemical procedure employing a planetary ball mill in excellent yields. Besides being a solvent-free reaction, the procedure has been successful in eliminating the need for employing any phase-transfer catalyst in the reaction. Copyright Taylor & Francis Group, LLC.

Aryl O- and S-galactosides and lactosides as specific inhibitors of human galectins-1 and -3: Role of electrostatic potential at O-3

Phase transfer catalyzed reaction was used for the high yielding synthesis of aryl 1-thio-β-d-galacto- and lacto-pyranosides carrying a panel of substituents on the phenyl groups. Best galectin-1 inhibitors were simple p-nitrophenyl thiogalactoside 5a for

Syntheses and Transformations of Glycohydrolase Substrates into Protein Conjugates Based on Michael Additions

The glycosyl chloride 1 and bromides 2 and 3 were stereospecifically transformed into p-nitrophenyl glycosides by phase transfer catalysis; these glycohydrolase substrates were reduced and N-acryloylated to afford Michael acceptors which reacted with amine functions of proteins.

Silver Imidazolate-assisted Glycosidations. Part 7. Synthesis of 1,2-trans-Linked Aryl Glycosides

Efficient preparations of 1,2-trans-linked aryl glycosides starting from fully acetylated glycopyranosyl bromides are described.The promoting system is silver imidazolate and zink chloride.