84034-75-3Relevant articles and documents
Glycosylated lanthanide cyclen complexes as luminescent probes for monitoring glycosidase enzyme activity
Burke, Helen M.,Gunnlaugsson, Thorfinnur,Scanlan, Eoin M.
, p. 9133 - 9145 (2016/10/07)
The development of synthetic chemical probes for the detection of enzymes is extremely important for biological, medicinal, and industrial applications. Here we report the synthesis of an array of novel glycosylated Tb(iii) complexes, their photophysical properties in solution, and their ability to function as luminescent probes for observing glycosidase enzyme activity in real time. Our initial studies into the application of these complexes for the detection of the Concanavalin A (ConA) lectin is also reported, highlighting the broad scope of these novel chemical probes.
Hexavalent glycoclusters having tris-bipyridine ferrous complex cores as minimum combinatorial libraries for probing carbohydrate–carbohydrate interactions
Nonaka, Yuki,Uruno, Ryuhei,Dai, Fumiko,Matsuoka, Ryoji,Nakamura, Masaki,Iwamura, Maho,Iwabuchi, Haruo,Okada, Takahiro,Chigira, Naoto,Amano, Yoshitsugu,Hasegawa, Teruaki
, p. 5456 - 5464 (2016/08/05)
2,2′-Bipyridines having two lactoside- or maltoside-appendages were prepared and then, complexed with ferrous ion to afford the corresponding tris-bipyridine ferrous complexes presenting hexavalent lactoside/maltoside clusters. Each of these complexes pro
Glycosynthase with broad substrate specificity-an efficient biocatalyst for the construction of oligosaccharide library
Wei, Jinhua,Lv, Xun,Lue, Yang,Yang, Gangzhu,Fu, Lifeng,Yang, Liu,Wang, Jianjun,Gao, Jianhui,Cheng, Shuihong,Duan, Qian,Jin, Cheng,Li, Xuebing
supporting information, p. 2414 - 2419 (2013/05/23)
A versatile glycosynthase (TnG-E338A) with strikingly broad substrate scope has been developed from Thermus nonproteolyticus β-glycosidase (TnG) by using site-directed mutagenesis. The practical utility of this biocatalyst has been demonstrated by the facile generation of a small library containing various oligosaccharides and a steroidal glycoside (total 25 compounds) in up to 100 % isolated yield. Moreover, an array of eight gluco-oligosaccharides has been readily synthesized by the enzyme in a one-pot, parallel reaction, which highlights its potential in the combinatorial construction of a carbohydrate library that will assist glycomic and glycotherapeutic research. Significantly, the enzyme provides a means by which glycosynthase technology may be extended to combinatorial chemistry.