84039-67-8Relevant academic research and scientific papers
Double carbonylation of aryl iodides with diethylamine catalyzed by dinuclear palladium complexes
Tsukada, Naofumi,Ohba, Yoichi,Inoue, Yoshio
, p. 436 - 443 (2003)
Dinuclear palladium complexes bridged by a novel PNNP ligand, N,N ′-bis[(2-diphenylphosphino)phenylformamidinate (dpfam), were found to be very efficient and selective catalysts for the double carbonylation of iodobenzene with diethylamine using K3PO4 as base and 1,4-dioxane as solvent with a TON up to 105 and selectivity of 96%.
Palladium nanoparticles on a pyridinium supported ionic liquid phase: a recyclable and low-leaching palladium catalyst for aminocarbonylation reactions
Adamcsik, Bernadett,Nagy, Enik?,Pekker, Péter,Skoda-F?ldes, Rita,Szabó, Péter,Urbán, Béla
, p. 23988 - 23998 (2020/07/14)
A new SILP (Supported Ionic Liquid Phase) palladium catalyst was prepared and characterized by 13C and 29Si CP MAS NMR, DTG, FTIR and TEM. The presence of the grafted pyridinium cations on the surface of the support was found to result in the formation of highly dispersed Pd nanoparticles with their diameter in the range of 1-2 nm. The catalyst was proved to be active not only in the aminocarbonylation of some model compounds but also in the synthesis of active pharmaceutical ingredients. Catalyst recycling and palladium leaching studies were carried out for the first time in aminocarbonylations leading to CX-546(1-(1,4-benzodioxan-6-ylcarbonyl)piperidine), Moclobemide, Nikethamide and a precursor of Finasteride. The latter reaction proves that not only aryl iodides but also an iodoalkene can be converted into the products with the help of the heterogeneous catalyst. The results show that the conditions should be always fine-tuned in the reactions of different substrates to achieve optimal results. Palladium loss was also observed to depend considerably on the nature of the reaction partners. This journal is
CATALYTIC DOUBLE CARBONYLATION OF ORGANOHALOGEN COMPOUNDS PROMOTED BY PALLADIUM COMPLEXES
Ozawa, Fumiyuki,Soyama, Hidehiko,Yamamoto, Takakazu,Yamamoto, Akio
, p. 3383 - 3386 (2007/10/02)
Various organohalogen compounds can be catalytically converted into α-keto amides on reaction with carbon monoxide and amines.Tertiary phosphine-coordinated palladium compounds are particularly suitable as the double carbonylation catalyst.
