840475-10-7Relevant academic research and scientific papers
Tosylhydrazide-promoted palladium-catalyzed reaction of β-aminoketones with o-dihaloarenes: Combining organocatalysis and transition-metal catalysis
Barluenga, Jose,Quinones, Noelia,Cabal, Maria-Paz,Aznar, Fernando,Valdes, Carlos
supporting information; experimental part, p. 2350 - 2353 (2011/04/21)
(Chemical Equation Presented) Working in tandem: Mannich adducts obtained by organocatalyzed processes are readily transformed into phenanthridine and quinoline derivatives by a Pd-catalyzed cascade reaction involving tosylhydrazide (TsNHNH2)-promoted cross-coupling followed by intramolecular amination (see scheme; MW=microwave). The enantioselectivity achieved in the organocatalytic reaction is maintained throughout the process.
Thermal effects in the organocatalytic asymmetric Mannich reaction
Rodriquez, Belen,Bolm, Carsten
, p. 2888 - 2891 (2007/10/03)
The proline-catalyzed direct asymmetric Mannich reaction between cyclohexanone, formaldehyde, and various anilines is thermally accelerated. With only 0.5 mol % of catalyst, Mannich products with up to 98% ee have been obtained after a short period of tim
Direct organocatalytic enantioselective α-aminomethylation of ketones
Ibrahem, Ismail,Zou, Weibiao,Casas, Jesús,Sundén, Henrik,Córdova, Armando
, p. 357 - 364 (2007/10/03)
The scope and limitations of the direct organocatalytic asymmetric α-aminomethylation of ketones are disclosed. The proline-catalyzed classical Mannich reactions between unmodified ketones, aqueous formaldehyde and aromatic amines furnished the desired Ma
