84055-96-9

Upstream product

• 84055-95-8 6-acetoxymethyl-2,3-dimethoxy-5-methyl-1,4-benzoquinone 
• 866023-74-7 2-hydroxymethyl-5,6-dimethoxy-3-methylphenol 
• 22383-86-4 2-hydroxy-3,4-dimethoxy-6-methylbenzaldehyde 
• 605-94-7 2,3-Dimethoxy-5-methyl-1,4-benzoquinone 
• 99590-11-1 2,5-diacetoxy-1-acetoxymethyl-3,4-dimethoxy-6-methylbenzene 
• 79-14-1 glycolic Acid 
• 178262-70-9 2,3,4,5-tetramethoxy-6-methylphenylmethanol 
• 127430-84-6 1-(chloromethyl)-2,3,4,5-tetramethoxy-6-methylbenzene 
• 35896-58-3 2,3,4,5-tetramethoxytoluene 

Downstream Products

• 202843-56-9 2-chloromethyl-5,6-dimethoxy-3-methyl-[1,4]benzoquinone 

Relevant academic research and scientific papers

Practical synthesis of 2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone

2,3-dimethoxy-5-hydroxymethyl-6-methyl-1,4-benzoquinone (V) was prepared with a 75 % yield by means of a reaction sequence starting from 2,3,4,5-tetramethoxytoluene via Blanc chloromethylation reaction, Kornblum oxidation, NaBH4 reduction and c

Single-step synthesis of idebenone from Coenzyme Q0 via free-radical alkylation under silver catalysis

Idebenone was synthesized directly by free-radical alkylation of 2,3-dimethyl-1,4-benzoquinone (Coenzyme Q0) with commercially available 11-hydroxyundecanoic acid in the presence of potassium peroxodisulfate and silver nitrate in a mixed solvent (CH3CN-H2O, 1:1) under mild condition in good yields (65%, based on Coenzyme Q0). The reaction is operationally simple and could be used in the preparation of other biologically Coenzyme Q analogues.

Synthesis and antioxidant activities of Coenzyme Q analogues

A series of 2,3-dimethoxy-5-methyl-1,4-benzoquinones (Coenzyme Q) substituted at the C-6 position with various groups were designed and synthesized based on the Coenzyme Q10 as potent antioxidant. In vitro antioxidant activities of these compounds were evaluated and compared with commercial antioxidant Coenzyme Q10 employing DPPH assay. All these synthesized Coenzyme Q analogues are found to exhibit good antioxidant activities. Of which Compound 8b bearing a N-benzoylpiperazine group at the C-6 position showed more potent inhibition of DPPH radical than Coenzyme Q10. All these results suggested the applicability of the Coenzyme Q analogues as potent antioxidants for combating oxidative stress.

An improved synthesis of the "miracle nutrient" coenzyme Q 10

(Chemical Equation Presented) A new route to the key coupling partner, chloromethylated CoQ0 (1), allows for direct formation of CoQ 10 (3) via nickel-catalyzed cross-coupling with the side chain in the form of an in situ-derived vin

Method of producing quinone derivatives

A quinone compound of the formula: STR1 wherein R stands for an alkyl group of 1 to 22 carbon atoms having at its terminal end a hydroxyl group which may be protected, can be obtained with industrial advantage by allowing a compound of the formula: STR2 t