84087-01-4

Basic information

• Product Name: Quinclorac
• Synonyms: dichloroquinolinicacid;quincloractech;BAS 514;3,7-DICHLORO-8-QUINOLINECARBOXYLIC ACID;3,7-DICHLOROQUINOLINE-8-CARBOXYLIC ACID;3，7-Dichloroquinoline acid-8;FACET;facet 75 df
• CAS NO: 84087-01-4
• Molecular Formula: C₁₀H₅Cl₂NO₂
• Molecular Weight: 242.06
• EINECS: 402-780-1
• Product Categories: HERBICIDE
• Mol File: 84087-01-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 274°C
• Boiling Point: 405.4 °C at 760 mmHg
• Flash Point: 100 °C
• Appearance: Colorless crystal
• Density: 1.7500
• Vapor Pressure: 2.27E-07mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• Storage Temp.: 0-6°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: -3.26±0.10(Predicted)
• BRN: 7761858
• CAS DataBase Reference: Quinclorac(CAS DataBase Reference)
• NIST Chemistry Reference: Quinclorac(84087-01-4)
• EPA Substance Registry System: Quinclorac(84087-01-4)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 2-24-37
• WGK Germany: 2
• RTECS: VB1984000
• Hazardous Substances Data: 84087-01-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 84087-01-4 differently. You can refer to the following data:
1. Quinclorac is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds , particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.
2. Quinclorac is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds, particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.

Definition

ChEBI: A quinolinemonocarboxylic acid that is quinoline-8-carboxylic acid in which the hydrogens at positions 3 and 7 have been replaced by chlorines. It is used (particularly as its dimethylamine salt, known as quinclorac-dimethylammonium) as a (rather persisten ) herbicide for the post-emergence control of weeds in rice, grass and turf. It is not approved for use within the European Union.

Pharmacology

The mechanism of action of quinclorac is controversial. Koo et al. (27) reported that quinclorac inhibited the incorporation of glucose into the cell wall of maize root cells. The synthesis of cellulose as well as some hemicellulose was inhibited at concentrations that inhibited whole plant growth, leading to the conclusion that quinclorac inhibits cell expansion by inhibiting glucose incorporation into the cell wall (27). These authors found that quinclorac inhibited root elongation in sensitive grasses at concentrations that inhibited cell wall biosynthesis. Cell wall biosynthesis in tolerant grasses was much less affected by quinclorac compared with sensitive grasses (28). Grossmann, on the other hand, believes that quinclorac acts as an auxinic herbicide in grasses as well as broadleaf plants, and that its herbicidal effects are due to production of cyanide (which is a byproduct of ethylene biosynthesis) and induction of the plant hormone abscisic acid (29). In this scenario, inhibition of cell wall biosynthesis would be considered a side effect, and not the primary cause of herbicidal injury. Differences in tolerance to quinclorac in this case are solely due to differences in ethylene induction, in that tolerant plants do not respond to quinclorac by synthesizing ethylene (29,30).

Metabolism

Quinclorac has been under development by BASF since 1982, and it has been marketed since 1984, as the herbicide Facet. Synthesis data are not currently available. Absorption and uptake of quinclorac is rapid, with 85% uptake in crabgrass within the first 30 minutes. Although uptake of quinclorac is rapid, translocation is generally poor, especially in sensitive plants. Tolerant species, such as Kentucky bluegrass, tend to transport more of the chemical away from the area of uptake. This may, in part, explain how tolerant plants are less affected by quinclorac. Quinclorac is metabolized very slowly in both sensitive and tolerant grass species. In leafy spurge, themajor metabolite found 7 days after foliar application of quinclorac was a pentosylglucose ester. In susceptible grasses, early symptoms of quinclorac activity include rapid chlorosis starting at the elongation zone of newly expanding leaves. This is followed by more widespread chlorosis and, eventually, necrosis. On the other hand, quinclorac seems to affect susceptible broadleaf plants as an auxinic herbicide. Symptoms in broadleaf plants begin with induction of ethylene biosynthesis and epinastic bending of shoots and leaves. This is followed by growth inhibition, chlorosis, wilting, and, finally, necrosis.

Toxicity evaluation

Quinclorac is nonflammable and noncorrosive, and it is stable in storage for at least 2 years. Quinclorac is classified as general use, with an oral LD50 > 2.61 g/kg in rats (31).

InChI:InChI=1/C10H5Cl2NO2/c11-6-3-5-1-2-7(12)8(10(14)15)9(5)13-4-6/h1-4H,(H,14,15)

Upstream product

• 158353-15-2 1-(3-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)-5-(methyl-2-propynylamino)-1H-pyrazole-4-carbonitrile 
• 84086-96-4 3,7-dichloro-8-chloromethyl quinoline 
• 64-19-7 acetic acid 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 87293-44-5 7-chloro-8-quinolinecarboxylic acid 
• 88347-01-7 3,7-dichloro-8-cyanoquinoline 

Downstream Products

• 84087-33-2 quinclorac methyl ester 
• 1463965-41-4 3,7-dichloro-N-(2-(m-tolyloxy)ethyl)quinoline-8-carboxamide 

Relevant articles and documents

Method for preparing 8-quinoline carboxylic acid and derivatives of 8-quinoline carboxylic acid

The invention discloses a method for preparing 8-quinoline carboxylic acid and derivatives thereof, which comprises the following steps: by using a compound I as a raw material, reacting with an oxidant at the temperature of 50-150 DEG C under normal pressure in a solvent under the action of a Cu-Co-X ternary composite catalyst to obtain a compound II; according to the method, the efficient Cu-Co-X ternary composite catalyst is adopted, the reaction is carried out at the temperature of 50-150 DEG C under normal pressure, the reaction condition is mild, the oxidation yield is remarkably increased, near-zero emission of three wastes is realized, the pollution problem is effectively solved, and the production cost is greatly reduced.

NOXIOUS ARTHROPOD CONTROL AGENT CONTAINING AMIDE COMPOUND

An object of the present invention is to provide a compound having the controlling activity on a noxious arthropod, and a noxious arthropod controlling agent containing an amide compound of formula (I): wherein X represents a nitrogen atom or a CH group, p represents 0 or 1, A represents a tetrahydrofuranyl group or the like, R1, R2, R3, R4, R5, R6 and R7 represent a hydrogen atom or the like, n represents 1 or 2, Y represents an oxygen atom or the like, m represents any integer of 0 to 7, and Q represents a C1-8 chain hydrocarbon group optionally having a phenyl group or the like, has the excellent noxious arthropod controlling effect.

Solid mixtures based on sulfonylureas and adjuvants

Solid mixtures comprising a) an active compound from the group consisting of the sulfonylureas, and b) an alkylpolyglucoside.