84097-20-1

Usage

Uses

Used in Pharmaceutical Industry:
2,6-dichloro-4-guanidino-pyrimidine is used as a therapeutic agent for its potential role in treating cancer. It targets the de novo pyrimidine biosynthesis pathway, which is essential for the proliferation of rapidly dividing cells, such as cancer cells. By inhibiting this pathway, the compound can potentially suppress tumor growth and reduce the viability of cancer cells.
Additionally, 2,6-dichloro-4-guanidino-pyrimidine is used as a potential treatment for autoimmune diseases. 2,6-dichloro-4-guanidino-pyrimidine's ability to modulate the immune system and interfere with the biosynthesis of pyrimidines may help in managing the overactive immune responses observed in autoimmune conditions.
In Antiviral Applications:
2,6-dichloro-4-guanidino-pyrimidine is used as an antiviral agent due to its potential to inhibit viral replication by targeting the host's pyrimidine biosynthesis pathway. This can limit the availability of pyrimidines required for viral DNA synthesis, thereby restricting the spread of the virus within the host.
In Antiprotozoal Applications:
2,6-dichloro-4-guanidino-pyrimidine is used as an antiprotozoal agent, showing promise in the treatment of infections caused by protozoan parasites. 2,6-dichloro-4-guanidino-pyrimidine's ability to inhibit the de novo pyrimidine biosynthesis pathway can disrupt the growth and reproduction of these parasites, offering a potential therapeutic strategy against protozoal diseases.
While 2,6-dichloro-4-guanidino-pyrimidine demonstrates promising potential in various medical applications, further research and clinical trials are necessary to fully understand its efficacy, safety profile, and optimal dosages for different therapeutic uses.

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 113-00-8 guanidine nitrate 
• 50-01-1 guanidine hydrochloride 

Relevant academic research and scientific papers

Investigations of Pt(II) coordination compounds with substituted guanidinopyrimidines

Some new chelates of platinum(II) with substituted guanidinopyrimidines have been prepared and characterized. On the basis of IR and UV-VIS spectra, the structure of the nearest environment of the central ion of these chelates has been characterized and the most likely structures of the obtained coordination compounds were proposed. In each chelate the square-planar coordination sphere of the Pt(II) ion is formed by the guanidinopyrimidine molecule and the halide ligand. Guanidinopyrimidine is the mono- or bidentate ligand binding through the nitrogen atoms of the guanidine group. Halides play a role of terminal and bridging ligands as well.

Preparation and Spectroscopic Investigation of Pd(II) Chelates with Substituted Guanidinopyrimidines

Some new chelates of palladium(II) with substituted guanidinopyrimidines have been prepared and characterized.On the basis of IR and UV-VIS spectra, the structure of the nearest environment of the central ion of these chelates has been characterized.Their ligands are bonded with metal ion via nitrogen atoms of the guanidine group. - Key words: complex compounds; synthesis; IR; VIS-spectra; magnetic susceptibilities

COORDINATION COMPOUNDS OF COPPER(II) WITH SUBSTITUTED GUANIDINOPYRIMIDINES

Some complexes of copper(II) with 4,6-dichloro-2-guanidinopyrimidine and 2,6-dichloro-4-guanidinopyrimidine have been prepared and characterized.On the basis of vibrational and electronic spectroscopy, magnetism and elemental analysis the structures of these chelates were identified.Thermal behavior of these complexes has also been studied.Substituted guanidinopyrimidines behave as bidentate ligands and are bonded via the N-atom of pyrimidine ring and N-atom of guanidine group with metal ion.

Synthesis of Some Substituted Guanidinopyrimidines and their Structural Assignment by 13C and 1H NMR

A series of substituted 2- and 4-guanidinopyrimidines were prepared by reaction of halopyrimidines with guanidine; alkylamino and amino substituents were introduced by subsequent halogen replacement by primary amines or ammonia or the catalytic reduction of nitro groups.Structural assignments were made on the basis of 13C and 1H nmr.A guanidinopteridine and a bispyrimidinylguanidine were also synthesized.Some unsuccessful reaction illustrated the low nucleophilic reactivity and thermal instability of the guanidine group.