84102-50-1Relevant academic research and scientific papers
INHIBITORS OF HEPATITIS C VIRUS REPLICATION
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Paragraph 0608-0609, (2019/05/15)
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
Mechanistic Insights on Orthogonal Selectivity in Heterocycle Synthesis
Maji, Arun,Reddi, Yernaidu,Sunoj, Raghavan B.,Maiti, Debabrata
, p. 10111 - 10118 (2018/10/20)
Recently, we have developed a method for catalytic regioselective synthesis of 2-substituted and 3-substituted benzofurans starting from phenols. The choice of reacting partner, olefin versus α,β-unsaturated acid, is critical to dictate the isomeric product formation. Instances are known where these olefinic partners did not complement each other and yield a similar outcome. In the current work, we have addressed this paradox with emphasis on (a) the origin of orthogonal selectivity and (b) the key requirements to expect complementary behavior. Experimental and computational studies provided important mechanistic insights. Electrostatic compatibility during migratory insertion and the positioning of the carboxylic acid moiety in catalytic steps are found to exert a paramount impact in determining the regioselectivity. The study offers a predictable single component tuning tool to control the regioselectivity.
INHIBITORS OF HEPATITIS C VIRUS REPLICATION
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Page/Page column 84, (2010/11/04)
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
Bisazo-benzofuran compounds, their use as charge carrier generating compounds and intermediates for their preparation
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, (2008/06/13)
There is provided an electrophotographic photoconductor comprising as a charge carrier generating substance a bisazo compound of the general formula (I): wherein R1and R2are the same or different, each representing a hydrogen atom, a
Syntheses of Biscationic, Trypanocidal 1-Benzofuran Compounds
Dann, Otto,Char, Helmut,Griessmeier, Helmut
, p. 1836 - 1869 (2007/10/02)
2-Phenyl-1-benzofurans with the substituents Br, NO2, CN, and -NH2, -NH-C(=NH)-NH2, -C(=NH)-NH2, in 4',5-position were synthesized. - For arylated formamidine derivatives a simple new preparation was found by reacting amine hydrochlorides with dimethylformamide in the presence of cyanamide. - Based on 5- or 6-cyano-1-benzofuran-2-carboxylates a series of α,ω-bis(1-benzofuran-2-yl) derivatives with cyano-, amidino-, or imidazolinyl groups in 5- or 6-position was prepared.
