26028-36-4

Basic information

• Product Name: 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: BUTTPARK 34\07-75;5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER;Methyl 5-broMobenzofuran-2-carboxylate;5-BroMo-2-benzofurancarboxylic Acid Methyl Ester;Methyl 5-bromo-1-benzofuran-2-carboxylate;Methyl5-bromobenzo[b]furan-2-carboxylate
• CAS NO: 26028-36-4
• Molecular Formula: C₁₀H₇BrO₃
• Molecular Weight: 255.06
• Mol File: 26028-36-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 314.7°C at 760 mmHg
• Flash Point: 144.1°C
• Appearance: /
• Density: 1.589
• Vapor Pressure: 0.000459mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER(26028-36-4)
• EPA Substance Registry System: 5-BROMOBENZOFURAN-2-CARBOXYLIC ACID METHYL ESTER(26028-36-4)

Safety Data

• Hazardous Substances Data: 26028-36-4(Hazardous Substances Data)

Usage

Uses

5-Bromobenzofuran-2-carboxylic acid methyl ester is used in the synthesis of biscationic, trypanocidal 1-benzofuran compounds.

InChI:InChI=1/C10H7BrO3/c1-13-10(12)9-5-6-4-7(11)2-3-8(6)14-9/h2-5H,1H3

Upstream product

• 624-61-3 acetylene dibromide 
• 1847-93-4 Kohlensaeure-<4-brom-phenyl>-methyl-ester 
• 67-56-1 methanol 
• 23145-07-5 5-bromobenzofuran 
• 67-66-3 chloroform 
• 1369143-28-1 4-bromobenzofuran-2-carboxylic acid 
• 10242-11-2 5-bromobenzo[b]furan-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 96-32-2 bromoacetic acid methyl ester 
• 1761-61-1 5-bromosalicyclaldehyde 
• 24581-99-5 methyl (4-bromo-2-formylphenoxy)acetate 

Downstream Products

• 84102-77-2 methyl 5-cyanobenzofuran-2-carboxylate 
• 38220-77-8 5-bromo-2-(hydroxymethyl)-1-benzofuran 
• 76313-71-8 methyl 5-(4-methoxyphenyl)benzofuran-2-carboxylate 
• 1126637-46-4 methyl 5-phenylbenzofuran-2-carboxylate 
• 62878-96-0 5-bromobenzofuran-2-carbonyl chloride 
• 10242-11-2 5-bromobenzo[b]furan-2-carboxylic acid 
• 23145-16-6 5-bromo-1-benzofuran-2-carbaldehyde 
• 73819-60-0 5-(2-Imidazolin-2-yl)-2-<4-<4-(2-imidazolin-2-yl)phenyl>-1,3-butadienyl>-1-benzofuran 
• 84224-00-0 5-(2-Imidazolin-2-yl)-2<4-<4-(2-imidazolin-2-yl)phenyl>-(E)-vinyl>-1-benzofuran 
• 84102-80-7 <(5-Cyan-1-benzofuran-2-yl)methyl>triphenylphosphoniumchlorid 
• 84224-32-8 5-(2-Imidazolin-2-yl)-2-<4-<4-(2-imidazolin-2-yl)phenyl>-1,3-butadienyl>-1-benzofuran-dihydrochlorid 
• 84223-86-9 2-<2-(6-Amidino-1-benzofuran-2-yl)ethyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84223-84-7 5-(2-Imidazolin-2-yl)-2<4-<4-(2-imidazolin-2-yl)phenyl>-(E)-vinyl>-1-benzofuran-dihydrochlorid 
• 84223-79-0 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 

Relevant articles and documents

Enantioselective Synthesis of Five-Membered-Ring Atropisomers with a Chiral Rh(III) Complex

Axially chiral atropisomeric compounds are widely applied in asymmetric catalysis and medicinal chemistry, and efficient methods for their synthesis are in high demand. This applies in particular to atropisomers derived from five-membered aromatic rings because their lower barrier for rotation among the biaryl axis limits their asymmetric synthesis. We report here an enantioselective C-H functionalization method using our chiral RhJasCp complex for the synthesis of the biaryl atropisomer types that can be accessed from three different five-membered-ring heterocycles.

Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and in Situ Alcoholysis

We report an efficient approach for direct alkoxycarbonylation of furans as well as other heteroarenes via a one-step copper-mediated reaction of three components (i.e., heteroarene, alcohol, and CHCl3). The copper additive was confirmed to simultaneously promote the reaction in three pathways: oxidant cracking, single electron transfer, and alcoholysis. By means of this protocol, various functionalized furancarboxylates and other heteroarenecarboxylates were facilely obtained in moderate to good yields.

HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE

The invention relates to heterocyclic compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their pharmaceutical compositions for use in medicine for the treatment of diseases or disorders associated with the modulation of calcium sensing receptor modulators (CaSR), like e.g. hyperparathyroidism, chronic renal failure and chronic kidney disease and their complications.