84102-89-6

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 4-formyl-3-hydroxyis used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be incorporated into a wide range of drug molecules, contributing to the development of new and innovative medications.
Used in Organic Synthesis:
As an intermediate in organic synthesis, Benzonitrile, 4-formyl-3-hydroxyplays a crucial role in the production of various organic compounds. Its versatility in chemical reactions enables the synthesis of a broad range of organic molecules, including dyes, pigments, and other chemical products.
Used in Dye and Pigment Production:
Benzonitrile, 4-formyl-3-hydroxyis utilized in the production of dyes and pigments due to its ability to impart color to various materials. Its unique chemical structure allows it to be used in the creation of a wide range of dyes and pigments, contributing to the development of new and innovative colorants for various industries.
Used in Chemical Product Manufacturing:
In addition to its applications in pharmaceuticals, dyes, and pigments, Benzonitrile, 4-formyl-3-hydroxyis also used in the manufacturing of other chemical products. Its versatility and unique chemical properties make it a valuable component in the production of various chemical compounds.
Used in Biological and Pharmacological Research:
Although further research is needed, Benzonitrile, 4-formyl-3-hydroxyhas been studied for its potential biological and pharmacological activities. Its unique chemical structure and properties make it a promising candidate for the development of new therapeutic agents and the advancement of our understanding of biological processes.

InChI:InChI=1/C8H7NO/c1-6-2-3-7(5-9)4-8(6)10/h2-4,10H,1H3

Upstream product

• 105942-10-7 3-fluoro-4-formylbenzonitrile 
• 88328-15-8 4-{[(E)-Pyridin-2-ylmethylimino]-methyl}-benzonitrile 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 105-07-7 4-cyanobenzaldehyde 
• 959934-76-0 tert-butyl (2E)-3-(4-cyano-2-methoxyphenyl)acrylate 
• 4421-08-3 3-methoxy-4-hydroxybenzonitrile 
• 21962-45-8 4-formyl-3-methoxy-benzonitrile 
• 84102-87-4 5-cyano-2-methylphenyl acetate 
• 3816-66-8 3-hydroxy-4-methylbenzonitrile 
• 84102-88-5 3-Acetoxy-4-(dibrommethyl)benzonitril 

Downstream Products

• 84103-00-4 6-Cyan-N-(4-cyanphenyl)-1-benzofuran-2-carboxamid 
• 84103-01-5 6-Amidino-N-(4-amidinophenyl)-1-benzofuran-2-carboxamid-dihydrochlorid 
• 84223-79-0 2-<2-(6-Amidino-1-benzofuran-2-yl)-(E)-vinyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84223-86-9 2-<2-(6-Amidino-1-benzofuran-2-yl)ethyl>-1-benzofuran-5-carboxamidin-dihydrochlorid 
• 84223-47-2 4',6-Bis(2-imidazolin-2-yl)-1-benzofuran-2-carboxanilid-dihydrochlorid 
• 84102-94-3 <(6-Cyan-2-benzofuran-2-yl)methyl>triphenylphosphoniumchlorid 
• 959984-36-2 5-cyano-2-formyl-phenyl trifluoromethanesulfonate 
• 202522-04-1 3-ethyl-4-formylbenzonitrile 
• 179254-05-8 3-benzyloxy-4-formylbenzonitrile 

Relevant academic research and scientific papers

Directed Hydroxylation of sp2 and sp3 C-H Bonds Using Stoichiometric Amounts of Cu and H2O2

The use of copper for C-H bond functionalization, compared to other metals, is relatively unexplored. Herein, we report a synthetic protocol for the regioselective hydroxylation of sp2 and sp3 C-H bonds using a directing group, stoichiometric amounts of Cu and H2O2. A wide array of aromatic ketones and aldehydes are oxidized in the carbonyl γ-position with remarkable yields. We also expanded this methodology to hydroxylate the β-position of alkylic ketones. Spectroscopic characterization, kinetics, and density functional theory calculations point toward the involvement of a mononuclear LCuII(OOH) species, which oxidizes the aromatic sp2 C-H bonds via a concerted heterolytic O-O bond cleavage with concomitant electrophilic attack on the arene system.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

Phenylglycine derivatives useful for treating disorders of the central nervous system

A pharmaceutical compound of the formula: STR1 in which R1 is hydrogen, hydroxy or C1-6 alkoxy, R2 is hydrogen, carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' where R' is hydrogen, C1-6 alkyl, C2-6 alkenyl or aryl C1-6 alkyl, R3 is hydrogen, hydroxy or C1-4 alkoxy, and R4 is fluoro, trifluoromethyl, nitro, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkylthio, heteroaryl, optionally substituted aryl, optionally substituted aryl C1-6 alkyl, optionally substituted aryl C2-6 alkenyl, optionally substituted aryl C2-6 alkynyl, optionally substituted aryloxy, optionally substituted aryl C1-6 alkoxy, optionally substituted arylthio, optionally substituted aryl C1-6 alkylthio or --CONR"R'", --SO2 NR"R"", --NR"R'", --OCONR"R"' or --SONR"R'" where R" and R'" are each hydrogen, C1-6 alkyl or aryl C1-6 alkyl, or R" and R'" together form a C3-7 alkylene ring; provided that (i) R1, R2 and R3 are not all hydrogen,and (ii) when R2 and R3 are hydrogen and R1 is hydroxy, R4 is not fluoro; or a salt or ester thereof.

Syntheses of Biscationic, Trypanocidal 1-Benzofuran Compounds

2-Phenyl-1-benzofurans with the substituents Br, NO2, CN, and -NH2, -NH-C(=NH)-NH2, -C(=NH)-NH2, in 4',5-position were synthesized. - For arylated formamidine derivatives a simple new preparation was found by reacting amine hydrochlorides with dimethylformamide in the presence of cyanamide. - Based on 5- or 6-cyano-1-benzofuran-2-carboxylates a series of α,ω-bis(1-benzofuran-2-yl) derivatives with cyano-, amidino-, or imidazolinyl groups in 5- or 6-position was prepared.