841233-89-4Relevant academic research and scientific papers
Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L- glutamic acid (GPE) modified at the α-carboxylic acid
Trotter, Nicholas S.,Brimble, Margaret A.,Harris, Paul W.R.,Callis, David J.,Sieg, Frank
, p. 501 - 517 (2007/10/03)
The synthesis of nine GPE* analogues, wherein the α-carboxylic acid group of glutamic acid has been modified, is described by coupling readily accessible N-benzyloxycarbonyl-glycyl-l-proline 2 with various analogues of glutamic acid. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glutamate residue on the observed neuroprotective properties of the endogenous tripeptide GPE.
Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): Synthesis and structure-activity relationships
Alonso De Diego, Sergio A.,Munoz, Pilar,Gonzalez-Muniz, Rosario,Herranz, Rosario,Martin-Martinez, Mercedes,Cenarruzabeitia, Edurne,Frechilla, Diana,Del Rio, Joaquin,Jimeno, M. Luisa,Garcia-Lopez, M. Teresa
, p. 2279 - 2283 (2007/10/03)
A series of GPE analogues, including modifications at the Pro and/or Glu residues, was prepared and evaluated for their NMDA binding and neuroprotective effects. Main results suggest that the pyrrolidine ring puckering of the Pro residue plays a key role
