841255-59-2Relevant academic research and scientific papers
3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase
Noe, Mark C.,Snow, Sheri L.,Wolf-Gouveia, Lilli A.,Mitchell, Peter G.,Lopresti-Morrow, Lori,Reeves, Lisa M.,Yocum, Sue A.,Liras, Jennifer L.,Vaughn, Marcie
, p. 4727 - 4730 (2007/10/03)
N-Hydroxy-3-hydroxy-4-arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure-activity relationships are reported. N-Hydroxy-3-hydroxy-4- arylsulfonyltetrahydropyranyl-3-carboxamides were designed as novel inhibitors of MMP-13 and aggrecanase based on known endocyclic hydroxamate inhibitors of matrix metalloproteinases. These compounds offer favorable physicochemical properties and low metabolic clearance. Synthesis and structure-activity relationships are reported.
