841286-80-4

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidinecarboxylic acid, 3-hydroxy-4,4-diMethoxy-, 1,1-diMethylethyl ester is used as a pharmaceutical compound for its potential therapeutic applications. The presence of various functional groups in its structure allows for interactions with biological targets, making it a candidate for the development of new drugs.
Used in Chemical Research:
1-Piperidinecarboxylic acid, 3-hydroxy-4,4-diMethoxy-, 1,1-diMethylethyl ester is used as a research chemical for studying the effects of its structural features on chemical reactivity and potential applications in various fields, such as material science and organic synthesis.
Used in Material Science:
1-Piperidinecarboxylic acid, 3-hydroxy-4,4-diMethoxy-, 1,1-diMethylethyl ester is used as a component in the development of new materials, such as polymers and coatings, due to its unique structural properties and potential for chemical modification.

Upstream product

• 67-56-1 methanol 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 124-41-4 sodium methylate 

Downstream Products

• 1130156-23-8 (±)-tert-butyl 3-hydroxy-4-oxopiperidine-1-carboxylate 
• 1171126-68-3 tert-butyl 3-benzyloxy-4,4-dimethoxypiperidine-1-carboxylate 
• 1232675-02-3 3-hydroxypiperidin-4-one hydrochloride 
• 1171126-69-4 tert-butyl 3-(benzyloxy)-4-oxopiperidine-1-carboxylate 
• 1361195-79-0 tert-butyl 3-(benzyloxy)-4-hydroxypiperidine-1-carboxylate 
• 325486-45-1 tert-butyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate 
• 1186688-49-2 benzyl 3-benzyloxy-4-oxopiperidine-1-carboxylate 
• 1188265-31-7 3-methoxy-4-oxopiperidine-1-carboxylic acid t-butyl ester 
• 1260639-98-2 tert-butyl 4-amino-3-methoxypiperidine-1-carboxylate 

Relevant academic research and scientific papers

Substituted pyridine compound and its method and use thereof

The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.

Synthesis method of 4-oxy-3,4-dihydro-2H-pyridine-1-tert-butyl formate

The invention relates to a synthesis method of 4-oxy-3,4-dihydro-2H-pyridine-1-tert-butyl formate, which mainly solves the technical problems that the cost is high and the environment is polluted due to the use of a noble metal reagent in the existing synthesis method, and severe reaction conditions are not easy to control. The synthesis method comprises the following steps: taking N-tert-butyloxycarboryl-4-piperidone as the raw material to react with iodine in the presence of sodium methoxide, so as to obtain 3-hydroxy-4,4-dimethoxy-piperidine-1-tert-butyl formate; allowing the 3-hydroxy-4,4-dimethoxy-piperidine-1-tert-butyl formate to react with an activating group to obtain 3-activating group-4,4-dimethoxy-piperidine-1-tert-butyl formate; under the action of alkali, carrying out an eliminating reaction to obtain 4,4-dimethoxy-3,4-dihydro-2H-pyridine-1-tert-butyl formate; and finally, removing a protecting group to obtain 4-oxy-3,4-dihydro-2H-pyridine-1-tert-butyl formate. This type compound is an important drug compound structure modification small molecule in the research field of new drug.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

1 -OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS

1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.

4- (5-CYANO-PYRAZOL-1-YL) -PIPERIDINE DERIVATIVES AS GPR 119 MODULATORS

Compounds that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein- coupled receptor GPR119 in animals are described herein.

INDOLYLPYRIMIDINES AS MODULATORS OF GPR119

The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions modulated by GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).

ASK1 INHIBITING PYRROLOPYRIMIDINE DERIVATIVES

This invention relates to pyrrolopyrimidine derivatives of formula (I): where R1, X, p, R4, R2and R3are as defined herein, and their use as pharmaceuticals.

Morpholinosulfur trifluoride (morph-DAST)-mediated rearrangement in the fluorination of cyclic α,α-dialkoxy ketones toward 1,2-dialkoxy-1,2-difluorinated compounds

The deoxofluorination of cyclic α,α-dialkoxy ketones with morpholinosulfur trifluoride (Morph-DAST) resulted in 1,2-dialkoxy-1,2- difluorinated carbo- and heterocyclic compounds. The reaction proceeds via a 1,2-alkoxy migration leading to mixtures of cis-

Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives

A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 8f, 8g, 8i and 8j with the potencies similar to or better than those of levofloxacin and IMB against Staphylococcus aureus and Staphylococcus epidermidis, worth further investigation.

Efficient synthesis of 3-alkoxy-4,4-difluoropiperidines

Fluorinated piperidines bearing an additional functional group at the heterocyclic ring are important building blocks for use in agrochemical or pharmaceutical chemistry. Therefore, for the first time 3-alkoxy-4,4- difluoropiperidines were synthesized by