841302-38-3Relevant articles and documents
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors
Simpkins, Ligaya M.,Bolton, Scott,Pi, Zulan,Sutton, James C.,Kwon, Chet,Zhao, Guohua,Magnin, David R.,Augeri, David J.,Gungor, Timur,Rotella, David P.,Sun, Zhong,Liu, Yajun,Slusarchyk, William S.,Marcinkeviciene, Jovita,Robertson, James G.,Wang, Aiying,Robl, Jeffrey A.,Atwal, Karnail S.,Zahler, Robert L.,Parker, Rex A.,Kirby, Mark S.,Hamann, Lawrence G.
, p. 6476 - 6480 (2007)
The synthesis and structure-activity relationships of novel dipeptidyl peptidase IV inhibitors replacing the classical cyanopyrrolidine P1 group with other small nitrogen heterocycles are described. A unique potency enhancement was achieved with β-branched natural and unnatural amino acids, particularly adamantylglycines, linked to a (2S,3R)-2,3-methanopyrrolidine based scaffold.
ADAMANTYGLYCINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS
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Page/Page column 41, (2008/06/13)
Compounds are provided having the formula (I) [Chemical Structure] wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n + m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
