84145-87-9Relevant articles and documents
Spectrophotometric determination of metronidazole and tinidazole via charge transfer complexation using chloranilic acid
Adegoke,Umoh,Soyinka
, p. 359 - 370 (2010)
A new spectrophotometric method was developed for the determination of two important nitroimidazoles; metronidazole (MZ) and tinidazole (TZ). The method was based on the charge-transfer (CT) complexation reaction of reduced forms of metronidazole and tinidazole as n-electron donors and chloranilic acid (CAA) as π-electron acceptor to form a purple-colored complex with a new absorption band at 520 nm which was adopted as the analytical wavelength. Molar absorptivities of 2.741 × 102 L M-1 cm-1 and 2.681 × 102 L M-1 cm-1 were obtained for MZ and TZ, respectively. Optimization of reducing agent and time of reduction revealed the superiority of metal hydrides over reducing metals. Reduction of MZ and TZ was completed at 30 °C within 10 min. Optimizations of temperature and time for the complexation reaction revealed that the reaction was completed at 30 °C within 5 min. A 60:40 mixture of 1,4-dioxane: acetonitrile was found to be the best diluting solvent for optimal detector response. The complexes were stable at room temperatures for weeks. Beer's law was observed in the concentration of 5-40 μg ml (MZ) and 4.8-79.2 μg ml-1 (TZ) with low limits of detection of 1.88 and 0.74 μg ml -1, respectively. Overall recoveries of MZ and TZ from quality control samples were 103.19 ± 2.05 (%RSD = 1.99, n = 12) and 101.63 ± 1.41 (%RSD = 1.39) over three days. There was no interference from commonly utilized tablet excipients. No significant difference existed between the results of the new method and the BP titrimetric procedures (p > 0.05). The new CT procedure described in this paper is simple, fast, convenient, accurate and precise and has the novelty of carrying out the reactions at room temperature compared to previously described procedures. The new method could be adopted as an alternative procedure for the quality assessment of MZ and TZ in bulk and dosage forms.
Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice
Salillas, Sandra,Alías, Miriam,Michel, Valérie,Mahía, Alejandro,Lucía, Ainhoa,Rodrigues, Liliana,Bueno, Jessica,Galano-Frutos, Juan José,De Reuse, Hilde,Velázquez-Campoy, Adrián,Carrodeguas, José Alberto,Sostres, Carlos,Castillo, Javier,Aínsa, José Antonio,Díaz-De-Villegas, María Dolores,Lanas, ángel,Touati, Eliette,Sancho, Javier
, p. 6102 - 6115 (2019/08/02)
Helicobacter pylori (Hp) infection is the main cause of peptic ulcer and gastric cancer. Hp eradication rates have fallen due to increasing bacterial resistance to currently used broad-spectrum antimicrobials. We have designed, synthesized, and tested redox variants of nitroethylene- and 7-nitrobenzoxadiazole-based inhibitors of the essential Hp protein flavodoxin. Derivatives of the 7-nitrobenzoxadiazole lead, carrying reduced forms of the nitro group and/or oxidized forms of a sulfur atom, display high therapeutic indexes against several reference Hp strains. These inhibitors are effective against metronidazole-, clarithromycin-, and rifampicin-resistant Hp clinical isolates. Their toxicity for mice after oral administration is low, and, when administered individually at single daily doses for 8 days in a mice model of Hp infection, they decrease significantly Hp gastric colonization rates and are able to eradicate the infection in up to 60% of the mice. These flavodoxin inhibitors constitute a novel family of Hp-specific antimicrobials that may help fight the constant increase of Hp antimicrobial-resistant strains.
Scale-up synthesis of zero-valent iron nanoparticles and their applications for synergistic degradation of pollutants with sodium borohydride
Ravikumar,Dubey, Swati,pulimi, Mrudula,Chandrasekaran, Natarajan,Mukherjee, Amitava
, p. 589 - 598 (2016/10/24)
The scale-up synthesis of nZVI (zero-valent iron nanoparticles) was optimized by response surface modeling (RSM). The synthesized nZVI was employed for synergistic degradation of metronidazole (MNZ) or methyl orange (MO) in the presence of sodium borohydr
Study of electrode kinetics and thermodynamic parameters of Metronidazole polarographically
Garg, Ashish,Sharda,Kumar, Yogesh,Meena, Om Prakash,Singh, Mahipat,Pandey
, p. 619 - 622 (2012/10/29)
The electrochemical reduction of antibacterial and antiprotozoal drug "Metronidazole" has been carried out in aqueous solution of different pH by direct current (DC) polarography. It exhibits two reduction peaks in acidic medium and one in basic medium. Along with different pH, studies of drug have been carried out with different concentrations of drug and at different temperatures. The reduction of MTZ was found to be irreversible so kinetic parameters (Kofh, αn) are evaluated using Meites-Israel and Gaur-Bhargava's methods. Thermodynamic parameters such as ΔHp&z.ast;, ΔHv&z.ast;, ΔG≠ and ΔS≠ are also evaluated.
