84186-33-4

Usage

Uses

Used in Pharmaceutical Industry:
Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl(9CI) is used as a potential active pharmaceutical ingredient for its possible anti-inflammatory properties, offering a new avenue for the treatment of inflammation-related conditions.
Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl(9CI) is used as a potential antiviral agent, suggesting its capacity to combat viral infections, which could be particularly valuable in the development of new antiviral medications.
Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl(9CI) is also considered for its potential anticancer properties, indicating its use in oncology research and drug development, where it may contribute to the discovery of new cancer therapies.
Further research is essential to fully understand the biological activities and establish the safety and efficacy of Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl(9CI) in various applications, ensuring its potential is harnessed responsibly and effectively.

Upstream product

• 602-01-7 1-methyl-2,3-dinitrobenzene 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 191794-09-9 4-(4-methyl-2-benzimidazolyl)-1-butanol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 84186-29-8 3-piperidino-2-nitrotoluene 
• 570-24-1 2-Methyl-6-nitroaniline 
• 84186-31-2 6-methyl-2-piperidinoaniline 

Relevant academic research and scientific papers

Ambident heterocyclic reactivity: Intramolecular alkylations of 2,4-disubstituted benzimidazoles

Alkali induced intramolecular cyclizations of 2-(3-chloropropyl)- and 2-(4-chlorobutyl)-4-substituted benzimidazoles bearing 4-nitro-, 4-amino-, and 4-methyl groups show enhanced N3/N1 regioselectivity compared to the corresponding intermolecular alkylations with 1-chlorobutane. The observed N1:N3 cyclization ratios vary from 94:6 to 10:90, with the largest preference for reaction at the 'congested' N3-site occurring in the 5-membered ring formation. In contrast, related base induced reactions of (2-benzimidazolyl)methyl chloroacetate and 3-(2-benzimidazolyl)propyl chloroacetate give excellent yields of macrocyclic dimeric systems. These results are interpreted as involving interplay between electrostatic field, through-bond electronic, and steric approach control factors within variable geometry S(N)2 transition state structures. Calculations (AMI and molecular mechanics) on these systems and conformational analysis of the expected transition states for the intramolecular cyclizations do not support any appreciable use of out-of-plane approach trajectories for these heterocyclic N- alkylation reactions.

SUBSTITUTION OF NITRO GROUPS IN 2,3-DINITROTOLUENE

The reaction of 2,3-dinitrotoluene with piperidine gives a mixture of 2-piperidino-3-nitrotoluene and 3-piperidino-2-nitrotoluene in a ratio of 3:7.