84186-33-4

Basic information

• Product Name: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI)
• Synonyms: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI)
• CAS NO: 84186-33-4
• Molecular Formula: C12H14N2
• Molecular Weight: 186.25296
• Product Categories: BENZIMIDAZOLE
• Mol File: 84186-33-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI)(84186-33-4)
• EPA Substance Registry System: Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI)(84186-33-4)

Safety Data

• Hazardous Substances Data: 84186-33-4(Hazardous Substances Data)

Usage

General Description

Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI) is a chemical compound with the formula C12H12N2. It is a heterocyclic compound that contains a benzimidazole ring fused to a pyridine ring, with a methyl group attached to the tetrahydro- structure. Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI) has potential pharmaceutical applications due to its unique structure and properties. It may exhibit biological activities such as anti-inflammatory, antiviral, or anticancer properties that could be explored for the development of new drugs. Further research is needed to determine the full range of biological activities and potential uses of Pyrido[1,2-a]benzimidazole, 1,2,3,4-tetrahydro-6-methyl- (9CI).

Upstream product

• 2687-25-4 3-methyl-1,2-benzenediamine 
• 191794-09-9 4-(4-methyl-2-benzimidazolyl)-1-butanol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 84186-29-8 3-piperidino-2-nitrotoluene 
• 602-01-7 1-methyl-2,3-dinitrobenzene 
• 570-24-1 2-Methyl-6-nitroaniline 
• 84186-31-2 6-methyl-2-piperidinoaniline 

Relevant articles and documents

Ambident heterocyclic reactivity: Intramolecular alkylations of 2,4-disubstituted benzimidazoles

Alkali induced intramolecular cyclizations of 2-(3-chloropropyl)- and 2-(4-chlorobutyl)-4-substituted benzimidazoles bearing 4-nitro-, 4-amino-, and 4-methyl groups show enhanced N3/N1 regioselectivity compared to the corresponding intermolecular alkylations with 1-chlorobutane. The observed N1:N3 cyclization ratios vary from 94:6 to 10:90, with the largest preference for reaction at the 'congested' N3-site occurring in the 5-membered ring formation. In contrast, related base induced reactions of (2-benzimidazolyl)methyl chloroacetate and 3-(2-benzimidazolyl)propyl chloroacetate give excellent yields of macrocyclic dimeric systems. These results are interpreted as involving interplay between electrostatic field, through-bond electronic, and steric approach control factors within variable geometry S(N)2 transition state structures. Calculations (AMI and molecular mechanics) on these systems and conformational analysis of the expected transition states for the intramolecular cyclizations do not support any appreciable use of out-of-plane approach trajectories for these heterocyclic N- alkylation reactions.