842150-42-9Relevant articles and documents
An expedient and short synthesis of a 6-iodo isocoumarin building block for the rubromycin family and its first palladium-catalyzed couplings
Brasholz, Malte,Reissig, Hans-Ulrich
, p. 2736 - 2738 (2004)
An efficient six-step synthesis of 6-iodo substituted isocoumarin 6 is presented, which is a suitable building block for the preparation of rubromycin type compounds. Key transformations of the sequence were achieved by directed ortho-lithiation, Horner-W
Towards the rubromycins: An efficient synthesis of a suitable isocoumarin precursor, its lactam analogue, and palladium-catalyzed couplings
Brasholz, Malte,Luan, Xiaosong,Reissig, Hans-Ulrich
, p. 3571 - 3580 (2007/10/03)
6-Iodoisocoumarin 4 and its aza-analogue, 6-iodo-1-oxo-isoquinoline 29, were efficiently prepared from vanillin in seven and six steps, respectively. Key transformations in their syntheses were achieved by directed ortho-lithiation and variations of Horne