877662-85-6

Upstream product

• 79-22-1 methyl chloroformate 
• 842150-42-9 tert-butyl-(4-[1,3]dioxan-2-yl-2-methoxyphenoxy)dimethylsilane 
• 121-33-5 vanillin 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 69404-94-0 O-tert-butyldimethylsilylvanillin 

Downstream Products

• 842150-47-4 methyl 7-benzyloxy-6-iodo-8-methoxy-1-oxo-1H-isochromene-3-carboxylate 
• 842150-44-1 methyl 6-formyl-3-hydroxy-4-iodo-2-methoxybenzoate 
• 877662-87-8 methyl (E)-3-benzyloxy-4-iodo-2-methoxy-6-(2-methoxycarbonyl-2-tert-butyldimethylsiloxyethynyl)benzoate 
• 877662-88-9 6-benzyloxy-3-hydroxy-5-iodo-7-methoxy-3H-benzofuran-1-one 
• 877662-86-7 methyl 3-benzyloxy-6-formyl-4-iodo-2-methoxybenzoate 
• 842150-43-0 methyl 6-formyl-3-hydroxy-2-methoxybenzoate 

Relevant academic research and scientific papers

An ortho-quinone methide based strategy towards the rubromycin spiroketal family

A method for the generation/in situ hetero-Diels-Alder cycloaddition of a trisubstituted ortho-quinone methide (o-QM) is described. Heating of ortho-hydroxybenzylamines was found to be a more effective strategy for the formation of o-QMs than use of the c

Towards the rubromycins: An efficient synthesis of a suitable isocoumarin precursor, its lactam analogue, and palladium-catalyzed couplings

6-Iodoisocoumarin 4 and its aza-analogue, 6-iodo-1-oxo-isoquinoline 29, were efficiently prepared from vanillin in seven and six steps, respectively. Key transformations in their syntheses were achieved by directed ortho-lithiation and variations of Horne

An expedient and short synthesis of a 6-iodo isocoumarin building block for the rubromycin family and its first palladium-catalyzed couplings

An efficient six-step synthesis of 6-iodo substituted isocoumarin 6 is presented, which is a suitable building block for the preparation of rubromycin type compounds. Key transformations of the sequence were achieved by directed ortho-lithiation, Horner-W