842167-45-7Relevant academic research and scientific papers
Synthesis of (±)-3-methoxyestra-1,3,5(10)-trienes by the repetitive use of Negishi reagent
Herrmann, Pavel,Kotora, Martin,Budesinsky, Milos,Saman, David,Cisarova, Ivana
, p. 1315 - 1318 (2007/10/03)
The repetitive use of Cp2ZrBu2 (Negishi reagent) was applied in the synthesis of three 3-methoxyestra-1,3,5(10)-trienone isomers within four steps from the advanced intermediate 11. The overall synthesis is based on three zirconium-m
Copper-catalyzed allylations of zirconocene intermediates generated from o-alkenyl or o-alkynylbenzyl ether derivatives and zirconocene-butene complex
Ikeuchi, Yutaka,Taguchi, Takeo,Hanzawa, Yuji
, p. 756 - 759 (2007/10/03)
(Chemical Equation Presented) o-Alkenyl or alkynyl benzylzirconocene intermediate, which was readily generated by the reaction of 2-alkoxymethyl-styrene or 2-alkoxymethyl-1-(trimethylsilylethynyl)-benzene derivative with zirconocene-butene complex (Negishi reagent, "Cp 2Zr"), reacted with allyl or propargyl halides in the presence of a catalytic amount of CuCl to give allylation or allenylation products. Conversion to Dane's diene, which is a key intermediate for estrone synthesis, was efficiently carried out by enyne olefin metathesis of the allylation products.
