842169-83-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL is used as an active pharmaceutical ingredient for the development of new therapeutic agents targeting the serotonin transporter. Its ability to modulate serotonin levels in the brain makes it a promising candidate for the treatment of depression, anxiety, and other related disorders.
Used in Agrochemical Industry:
(R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL is used as a key intermediate in the synthesis of agrochemical products, contributing to the development of innovative solutions for crop protection and pest management.
Used in Research and Drug Discovery:
(R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL is used as a research tool in neuroscience, aiding in the understanding of the role of serotonin in the brain and its implications in various neurological and psychiatric disorders. It also serves as a precursor in the synthesis of other functional molecules for further exploration and development of novel therapeutic agents.
Used in Industrial Applications:
(R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL is used as a precursor in the synthesis of other functional molecules for various industrial applications, such as the development of new materials, catalysts, and other specialty chemicals.

Upstream product

• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 842169-80-6 1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine 
• 943731-44-0 C₁₆H₁₃BrF₃N 
• 336105-31-8 N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide 
• 842169-81-7 1-(4-bromo-phenyl)-2,2,2-trifluoro-1-methoxy-ethylamine 
• 1258542-31-2 (Rs,R)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-tert-butanesulfinamide 

Downstream Products

• 778565-93-8 (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine 
• 1448682-01-6 N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]methanesulfonamide 
• 1448682-02-7 N-[(1S)-2,2,2-trifluoro-1-(4-formylphenyl)ethyl]methanesulfonamide 

Relevant academic research and scientific papers

Unprecedented catalytic asymmetric reduction of N-H imines

(Chemical Equation Presented) Addition of lithium bis(trimethylsilyl)amide to perfluorinated ketones 1a-j affords (E)-N-TMS-ketimines 2a-j that are reduced in situ to afford racemic perfluoromethylated amine hydrochloride salts 3a-j in 54-97% yields. Solv

NOVEL BENZYL SULFONAMIDE COMPOUNDS USEFUL AS MOGAT-2 INHIBITORS

The present invention provides compounds of Formula I. Wherein Rl, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the comp

One-pot asymmetric synthesis of α-trifluoromethylated amines from α-trifluoromethyl ketones

Diastereoselective reduction of (Rs)-N-tert-butanesulfinyl α-trifluoromethyl ketimines formed in situ from the corresponding α-trifluoromethyl ketones and N-tert-butanesulfinamide has been achieved, and either diastereomer of N-tert-butanesulfinyl α-trifl

Substituted bis-amide metalloprotease inhibitors

This invention relates to substituted bis-amide pyrimidine compounds of Formula (I), which are useful for the treatment of metalloprotease mediated diseases, in particular MMP-13 related diseases.

Synthesis of alpha fluoroalkyl amines

This invention describes the reaction of an alpha fluoroalkyl ketone with a bis(trialkylsilyl)amide to give a stable N-trialkylsilyl imine. Treatment of the N-trialkylsilyl imine with an alcohol leads to solvolysis of the trialkylsilyl group and yields a

REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B

The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.

Stereoselective nucleophilic trifluoromethylation of N-(tert-butylsulfinyl)imines by using trimethyl(trifluoromethyl)silane

A very general reaction is presented to achieve the nucleophilic transfer of "CF3" to chiral N-(tert-butylsulfinyl)imines in high yield and high stereoselectivity (see reaction scheme). Tetrabutylammonium difluorotriphenylsilicate (TBAT) functi