842169-83-9

Basic information

• Product Name: (R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL
• Synonyms: (R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL;(R)-1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROCHLORIDE;BenzeneMethanaMine, 4-broMo-a-(trifluoroMethyl)-, hydrochloride, (aR)-;(1R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUORO-ETHANAMINE HCL;(R)-1-(4-Bromophenyl)-2,2,2-trifluoroethanamine hydrochloride;(1R)-1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-amine hydrochloride;(1R)-1-(4-Bromophenyl)-2,2,2-trifluoroethanamine hydrochloride (1 :1)
• CAS NO: 842169-83-9
• Molecular Formula: C8H8BrClF3N
• Molecular Weight: 290.51
• Mol File: 842169-83-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL(842169-83-9)
• EPA Substance Registry System: (R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL(842169-83-9)

Safety Data

• Hazardous Substances Data: 842169-83-9(Hazardous Substances Data)

Usage

General Description

The chemical (R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL is a salt form of the compound with the same name, which is primarily used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is a selective inhibitor of the serotonin transporter and has potential applications in the treatment of depression, anxiety, and other related disorders. This chemical is characterized by its ability to modulate the release of serotonin in the brain, making it a valuable tool for research and drug discovery in the field of neuroscience. Additionally, it is also used in the development of new therapeutic agents and as a precursor in the synthesis of other functional molecules for various industrial applications.

Upstream product

• 1258542-31-2 (Rs,R)-N-(1-(4-bromophenyl)-2,2,2-trifluoroethyl)-tert-butanesulfinamide 
• 842169-81-7 1-(4-bromo-phenyl)-2,2,2-trifluoro-1-methoxy-ethylamine 
• 336105-31-8 N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 842169-80-6 1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine 
• 943731-44-0 C₁₆H₁₃BrF₃N 

Downstream Products

• 1448682-02-7 N-[(1S)-2,2,2-trifluoro-1-(4-formylphenyl)ethyl]methanesulfonamide 
• 1448682-01-6 N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]methanesulfonamide 
• 778565-93-8 (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine 

Relevant articles and documents

Unprecedented catalytic asymmetric reduction of N-H imines

(Chemical Equation Presented) Addition of lithium bis(trimethylsilyl)amide to perfluorinated ketones 1a-j affords (E)-N-TMS-ketimines 2a-j that are reduced in situ to afford racemic perfluoromethylated amine hydrochloride salts 3a-j in 54-97% yields. Solv

One-pot asymmetric synthesis of α-trifluoromethylated amines from α-trifluoromethyl ketones

Diastereoselective reduction of (Rs)-N-tert-butanesulfinyl α-trifluoromethyl ketimines formed in situ from the corresponding α-trifluoromethyl ketones and N-tert-butanesulfinamide has been achieved, and either diastereomer of N-tert-butanesulfinyl α-trifl

Synthesis of alpha fluoroalkyl amines

This invention describes the reaction of an alpha fluoroalkyl ketone with a bis(trialkylsilyl)amide to give a stable N-trialkylsilyl imine. Treatment of the N-trialkylsilyl imine with an alcohol leads to solvolysis of the trialkylsilyl group and yields a